不同剂量的川芎嗪对急性缺血性脑血管疾病的疗效观察

作者	单位
蔡永亮	安徽中医学院神经病学研究所!合肥230031
任明山	安徽中医学院神经病学研究所!合肥230031
杨任民	安徽中医学院神经病学研究所!合肥230031
王共强	安徽中医学院神经病学研究所!合肥230031

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中文摘要:

目的 :探讨不同剂量的川芎嗪对急性缺血性脑血管疾病 (ICVD)的临床疗效及血液流变学的影响。方法 :69例ICVD患者随机分为A组 (川芎嗪 12 0mg)、B组 (川芎嗪 2 4 0mg)、C组 (川芎嗪 4 80mg) 3组 ,观察 3组患者治疗前后临床疗效、神经功能缺损评分及血液流变学指标的变化。结果 :神经功能缺损评分、B组、C组与治疗前比较 ,差异有显著性 ;总有效率 :A、C两组间比较 ,差异有显著性 ;血液流变学 ,与治疗前比较 ,A组 1项、B组 3项、C组 7项差异有显著性。结论 :大剂量川芎嗪治疗ICVD具有临床疗效好 ,血液流变学改善明显 ,基本无因药物剂量大而出现的副反应等优点

英文摘要:

Objective: To compare clinical curative effect of acute ischemic cerebrovascular diseases (ICVD) treated with different dosage of ligustrazine and to observe the effect of ligustrazine on hemorrheology. Methods: Sixty nine patients with ICVD were randomized into three groups, the Group A, B and C treated with 120mg, 240mg and 480mg of ligustrazine respectively, the clinical curative effect, the changes in nerve function deficit score and hemorrheologic parameters before and after treatment were observed. Results: The clinical curative effect and improvement of hemorrheologic parameters in Group C were better than those in Group A and B significantly (P<0 05,P<0 01 respectively). Ligustrazine also showed obvious effect in lowering blood level of fibrinogen in Group C. Conclusion: Treatment of acute ICVD with large dose of ligustrazine is good in improving clinical effect and hemorrheology, and without side effect basically.

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