益肾祛毒胶囊治疗慢性肾功能衰竭的实验研究

作者	单位
王国柱	WANG Guozhu, LI Caixi, JIN Long, et al. Postgraduate School of China Academy of TCM, Beijing (100700
李彩熙	WANG Guozhu, LI Caixi, JIN Long, et al. Postgraduate School of China Academy of TCM, Beijing (100700
金龙	WANG Guozhu, LI Caixi, JIN Long, et al. Postgraduate School of China Academy of TCM, Beijing (100700
李军梅	WANG Guozhu, LI Caixi, JIN Long, et al. Postgraduate School of China Academy of TCM, Beijing (100700
刘建勋	WANG Guozhu, LI Caixi, JIN Long, et al. Postgraduate School of China Academy of TCM, Beijing (100700
栗德林	WANG Guozhu, LI Caixi, JIN Long, et al. Postgraduate School of China Academy of TCM, Beijing (100700

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中文摘要:

目的 :探讨益肾祛毒胶囊对实验性慢性肾功能衰竭 (简称慢性肾衰 )大鼠的治疗作用机理。方法 :用阳离子化牛血清白蛋白造成大鼠膜性肾病诱发慢性肾衰后 ,再用益肾祛毒胶囊大、小剂量灌胃治疗5周 ,以包醛氧化淀粉作阳性对照药。结果 :益肾祛毒胶囊能显著降低大鼠 2 4h尿蛋白、血清肌酐、尿素氮、血清循环免疫复合物 (P <0 0 1,P <0 0 5) ,且肾系数变小 (P <0 0 1) ,肾小球内有核细胞数减少 (P <0 0 1) ,肾小管内蛋白管型显著减少 (P <0 0 1) ,免疫荧光强度显著减弱 (P <0 0 1) ,光镜、电镜示肾脏病理明显改善。结论 :益肾祛毒胶囊能明显改善肾功能 ,抑制慢性肾衰的发展

英文摘要:

Objective: To study the mechanism of action of Yishen Qudu capsule (YSQDC) in experimental rat model of chronic renal failure (CRF). Methods: Membranous nephropathy model was induced by cationized bovine serum albumin intravenous administration in rats for 7 weeks and developed to CRF. The model was then treated with YSQDC of large or small dose by gastrogavage for 5 weeks. Oxidated starch was used in the control group. Results: YSQDC could reduce proteinuria, serum creatinine, blood urea nitrogen, total cholesterol, triglyceride and serum circulating immune complex (P<0 01 or P<0 05), it also reduced the kidney coefficient, glomerular cells and tubular protein cast significantly (all P<0 01). The strength of immune fluorescence weakened remarkably (P<0 01). The pathological lesions improved significantly after treatment under light and electron microscopic examination. Conclusion: YSQDC could improve renal function significantly and inhibit the progression of CRF.

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