不同中药注射剂对2型糖尿病并发急性脑梗死应激激素和免疫细胞因子的影响

Effect of Different Injections of Chinese Herbal Medicine on Stress Hormones and Immune Cell Factors in Patients of Type 2 Diabetes Mellitus Complicated with Acute Cerebral Infarction

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中文关键词: 2型糖尿病脑梗死中药注射剂应激激素免疫细胞因子

英文关键词:type 2 diabetes mellitus cerebral infarction injection of Chinese herbal medicine stress hormone immune cell factor

基金项目:广州中医药大学科研课题!(No .980 0 1 )

作者	单位
谌剑飞	广州中医药大学附属珠海市中医院!广东519015
马雅玲	广州中医药大学附属珠海市中医院!广东519015
梁浩荣	广州中医药大学附属珠海市中医院!广东519015

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中文摘要:

目的 :探讨不同中药注射剂对 2型糖尿病并发急性脑梗死患者应激激素和免疫细胞因子的影响及其临床意义。方法 :用放射免疫分析法 (RIA)对使用蛇毒制剂 (降纤酶 )、刺五加及金钠多 (银杏叶提取物 )注射液 3组病例 (各为 32、2 0、12例 )进行治疗前后促肾上腺皮质释放激素 (CRH)、促肾上腺皮质激素(ACTH)、皮质醇 (CS)、肿瘤细胞坏死因子 (TNFα)与白细胞介素 6(IL 6)含量检测 ,分析其变化特点 ,并与健康人组 ( 30名 )作比较。结果 :( 1) 3组患者入院治疗前应激激素与免疫细胞因子水平均显著高于健康人组(P <0 0 1) ;( 2 )治疗后 3组患者可随其含量的下降而显见改善 ,且以降纤酶组最为突出 (P <0 0 1)。结论 :3种中药注射剂对本病的作用机制与应激激素和免疫细胞因子水平关系密切 ,监测其变化对评价其疗效 ,阐明中药药理有重要临床价值

英文摘要:

Objective: To investigate the effect and clinical significance of different injections of Chinese herbal medicine on stress hormones and immune cell factors in treating patients of type 2 diabetes mellitus complicated with acute cerebral infarction. Methods: Patients were divided into three groups, treated with Defibrase injection (DI, n=32), Acanthopanax injection (AI, n=20) and Ginaton injection (GI,n=12) respectively. Parameters,including corticotropin releasing hormone (CRH), adrenocoticortropic hormone (ACTH), cortisol (CS), tumor necrosis factor α (TNFα) and interleukin 6 (IL 6) were determined using RIA in patients before and after treatment. The changes of parameters were analyzed and compared with those of healthy subjects for control. Results: (1) Levels of all the above mentioned parameters in all the three treated groups were higher than those in the healthy control group (P<0 01); (2) All parameters were reduced after treatment in the three treated groups and the optimal effect was shown in the DI group (P<0 01). Conclusion: The beneficial action of the three injections is closely related with the levels of stress hormones and immune cell factors, therefore, to monitor dynamically the changes of CRH, ACTH, CS, TNFα and IL 6 is of important significance in evaluation of therapeutic effect and elucidation of the pharmacology of Chinese herbal medicine.

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