中药神龙口服液配合放射治疗鼻咽癌的临床观察

作者	单位
朱小东	ZHU Xiaodong, WANG Anyu, WANG Shaofeng, et al. Guangxi Autonomous Regional Cancer Hospital, Cancer Hospital of Guangxi Medical University, Nanning (530021
王安宇	ZHU Xiaodong, WANG Anyu, WANG Shaofeng, et al. Guangxi Autonomous Regional Cancer Hospital, Cancer Hospital of Guangxi Medical University, Nanning (530021
王绍丰	ZHU Xiaodong, WANG Anyu, WANG Shaofeng, et al. Guangxi Autonomous Regional Cancer Hospital, Cancer Hospital of Guangxi Medical University, Nanning (530021
王仁生	ZHU Xiaodong, WANG Anyu, WANG Shaofeng, et al. Guangxi Autonomous Regional Cancer Hospital, Cancer Hospital of Guangxi Medical University, Nanning (530021
陈龙	ZHU Xiaodong, WANG Anyu, WANG Shaofeng, et al. Guangxi Autonomous Regional Cancer Hospital, Cancer Hospital of Guangxi Medical University, Nanning (530021
李龄	ZHU Xiaodong, WANG Anyu, WANG Shaofeng, et al. Guangxi Autonomous Regional Cancer Hospital, Cancer Hospital of Guangxi Medical University, Nanning (530021
陆海杰	ZHU Xiaodong, WANG Anyu, WANG Shaofeng, et al. Guangxi Autonomous Regional Cancer Hospital, Cancer Hospital of Guangxi Medical University, Nanning (530021

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中文摘要:

目的 :观察中药神龙口服液配合放射治疗鼻咽癌的效果。方法 :应用中药制剂神龙口服液配合放射治疗鼻咽癌 60例 (综合组 ) ,并与单纯放射治疗的 60例 (单放组 )进行急性毒副反应、细胞免疫功能及临床疗效对比观察。结果 :( 1)综合组急性毒副反应明显轻于单放组 (P <0 0 5) ;( 2 )两组鼻咽部及颈部肿瘤消退率差异无显著性 (P >0 0 5) ;( 3)综合组鼻咽部及颈部肿瘤消退时的放射治疗剂量 (简称肿瘤消退剂量 )明显低于单放组 (P <0 0 1) ;( 4 )综合组放疗前后T淋巴细胞亚群无显著变化 ,而单放组OKT3、OKT4 、OKT4 /OKT8在放疗后显著降低 ,与放疗前比较差异有显著性 (P <0 0 5) ;( 5)综合组生存率较单放组高 ,但差异无显著性 (P =0 0 518)。结论 :中药神龙口服液配合放射治疗鼻咽癌能减轻放疗副反应 ,改善机体细胞免疫功能 ,降低肿瘤消退剂量 ,具有放射增敏的效果 ,可能提高远期生存率

英文摘要:

Objective: To observe the effect of Shenlong Oral Liquid (SLOL) combined with radiotherapy in treating nasopharyngeal carcinoma (NPC). Methods: Effects of the combination therapy, including clinical effect, changes of cellular immunity and side effects, in treating 60 NPC patients (treated group) were observed and compared with those of the other 60 patients treated with radiotherapy alone (control group). Results: (1) The side effect of radiation in the treated group was lower than that in the control group significantly (P<0 05); (2) The immediate regression rate of nasopharyngeal and neck tumor in the two groups was not different significantly (P>0 05); (3)The doses for complete remission of nasopharyngeal and neck tumor in the treated group was lower than that in the control group (P<0 01); (4) No change of T lymphocyte subsets was found in the treated group after treatment, but in the control group, OKT 3, OKT 4 and OKT 4/OKT 8 ratio were markedly decreased (P<0 05); (5) The survival rate in the treated group was higher than that in the control group, but without statistical significance (P=0.0518). Conclusion: The combination therapy of NPC by SLOL and radiotherapy is able to reduce side effect of radiotherapy, improve the cellular immunity, reduce the dose of radiation for tumor remission and enhance the therapeutic effect of radiotherapy, it might raise the survival rate of NPC patients.

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