血清促炎、抗炎因子在急性感染患者中的动态变化及中药干预的影响

Dynamic Changes of Serum Pro Inflammatory Cytokines and Anti Inflammatory Cytokines in Patients with Acute Infection and the Effect of Chinese Herbal Medicine Intervention

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DOI：

中文关键词: 感染内毒素细胞因子中药

英文关键词:infection endotoxin cytokines Chinese herbal medicine

基金项目:

作者	单位
齐文杰	北京友谊医院感染内科!北京100050
任爱民	北京友谊医院感染内科!北京100050
张淑文	北京友谊医院感染内科!北京100050
王宝恩	北京友谊医院感染内科!北京100050

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中文摘要:

目的 :了解促炎、抗炎细胞因子在急性感染患者中的动态变化 ,并探讨中药 912液的治疗作用。方法 :采用鲎试剂基质偶氮显色定量法及酶联免疫吸附法 ,对 4 0例急性感染患者 (随机分为两组 ,普通治疗组 2 0例 ,中药 912液加普通治疗组 2 0例 )测定治疗前后血浆内毒素、血清促炎因子 (TNFα、IL 6)、抗炎因子 (sTNF RI、IL 4、IL 10 )的水平。结果 :急性感染患者早期即出现内毒素血症 ,促炎因子 (TNFα、IL 6)及抗炎因子 (sTNF RI、IL 4、IL 10 )均呈现不同程度的升高 ,两者水平变化基本平行 ,尤以IL 6、sTNF RI、IL 4、IL 10明显 ;TNFα、IL 6、sTNF RI与APACHEⅢ评分呈明显正相关。经治疗随病情好转 ,内毒素及炎症介质呈现不同程度的下降 ,而中药 912液加普通治疗组内毒素及TNFα、IL 6、IL 10下降幅度显著 ,优于普通治疗组 (P <0 0 5)。结论 :内毒素、促炎因子及抗炎因子在急性感染中起重要作用 ,可作为评估感染性疾病病情严重程度的指标 ,中药 912液使内毒素、TNFα、IL 6、IL 10水平下降 ,抑制sTNF RI下降 ,促进疾病恢复

英文摘要:

Objective: To study the dynamic changes of serum pro inflammatory cytokines and anti inflammatory cytokines in patients with acute infection and to explore the effect of 912 compound, a Chinese herbal preparation for intervention. Methods: Forty patients with acute infection were randomly divided into 2 groups, 20 in the 912 group and 20 in the control group, and the levels of plasma endotoxin (lipopolysaccharide, LPS), serum pro inflammatory cytokines, including tumor necrosis factor α (TNF α) and interleukin 6 (IL 6) and anti inflammatory cytokines, including soluble TNF RI, IL 4 and IL 10 were measured before and after treatment by using limulus reagent stroma azo colored quantitative method and enzyme linked immunosorbent assay (ELISA). Results: The level of LPS increased at the early stage of acute infection, the levels of pro and anti inflammatory cytokines were all elevated in various degrees, particularly obvious in IL 6, sTNF RI, IL 4 and IL 10 and the elevations of the two were basically parallel. The TNF α, IL 6 and sTNF RI were positively related with APACHE Ⅲ scoring. The levels of LPS and inflammatory cytokines reduced to a different extent in accord with the improvement of condition after treatment, the levels of LPS, TNF α, IL 6 and IL 10 lowered more significantly in the 912 group than those in the control group (P<0 05). Conclusions: LPS, pro inflammatory and anti inflammatory cytokines play important roles in the acute infection process, they were important indexes for evaluating severity of infectious diseases. The Chinese herbal preparation 912 compound could reduce the blood levels of LPS, TNF α, IL 6, IL 10 and prevent the decrease of sTNF RI so as to promote the recovery of patients.

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