茵陈胆道汤对急性胆管炎血浆纤维连结蛋白、胆汁血栓素A<sub>2</sub>和前列环素的影响

Effect of Yinchen Dandao Decoction on Plasma Fibronectin, Biliary Thromboxane A₂ and Prostaglandin I₂ in Human and Animal Suffering from Acute Cholangitis

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DOI：

中文关键词: 茵陈胆道汤急性胆管炎纤维连结蛋白血栓素A2 前列环素

英文关键词:Yinchen Dandao decoction acute cholangitis fibronectin thromboxane A 2 prostaglandin I 0

基金项目:

作者	单位
苗雄鹰	MIAO Xiongying, ZHUANG Zan′gen, LIANG Lufeng, et al. The Second Affiliated Hospital of Hunan Medical University, Changsha (410011
庄赞根	MIAO Xiongying, ZHUANG Zan′gen, LIANG Lufeng, et al. The Second Affiliated Hospital of Hunan Medical University, Changsha (410011
梁路峰	MIAO Xiongying, ZHUANG Zan′gen, LIANG Lufeng, et al. The Second Affiliated Hospital of Hunan Medical University, Changsha (410011
钟德午	MIAO Xiongying, ZHUANG Zan′gen, LIANG Lufeng, et al. The Second Affiliated Hospital of Hunan Medical University, Changsha (410011
王群伟	MIAO Xiongying, ZHUANG Zan′gen, LIANG Lufeng, et al. The Second Affiliated Hospital of Hunan Medical University, Changsha (410011
黄生福	MIAO Xiongying, ZHUANG Zan′gen, LIANG Lufeng, et al. The Second Affiliated Hospital of Hunan Medical University, Changsha (410011
李永国	MIAO Xiongying, ZHUANG Zan′gen, LIANG Lufeng, et al. The Second Affiliated Hospital of Hunan Medical University, Changsha (410011

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中文摘要:

目的 :探讨茵陈胆道汤治疗急性胆管炎的作用机制。方法 :2 4例急性胆管炎患者和 36例胆管结石患者分别随机分为服药组和对照组 ,均经手术治疗 ,服药组于术后第 3天开始服用茵陈胆道汤 ,连服7天。观察服药前后血浆纤维连结蛋白 (FN)和胆汁中血栓素A2 (TXA2 )及前列腺环素 (PGI2 )含量的变化。同时将兔制成急性胆管炎模型并设实验对照组 ,两组兔分别随机分为服药组和对照组 ,观察服药前后FN和胆汁中TXA2 、PGI2 含量的变化。结果 :胆管炎患者术前FN明显低于胆管结石组 (P <0 0 1) ,术后服药组则明显上升 ,与对照组比较差异有显著性 (P <0 0 1) ;胆管结石组也有类似变化。胆管炎组患者胆汁中TXA2 和PGI2 含量均明显高于胆管结石组 (P <0 0 1,P <0 0 5) ;服药后均显著下降 (P <0 0 1)。胆管炎兔服药组FN显著升高 (P <0 0 1) ;胆管炎兔胆汁TXA2 和PGI2 含量显著高于对照组 (P <0 0 1)。结论 :茵陈胆道汤能升高FN和降低胆汁中TXA2 和PGI2 水平 ,这可能是其治疗急性胆管炎的作用机理之一。

英文摘要:

To study the therapeutic mechanism of Yinchen Dandao decoction (YCDDD) in treating acute cholangitis. Methods: Twenty-four patients with acute cholangitis and 36 cholangiolithiasis patients were randomly classified into the treated group and the control group, and all of these patients had undergone surgical operation. The treated group were given orally YCDDD 3 days after operation for 1 week, and plasma fibronectin (FN), biliary thromboxane A 2 (TXA 2) and prostaglandin I 2 (PGI 2 ) were measured and compared before and after oral administration of the drug. The models of cholangitis were established in rabbits, which were also randomly grouped into the treated group and the control group, and the same parameters (FN, TXA 2, PGI 2) were observed as in rabbits. Results: The level of FN was significantly lower in cholangitis patients than that in the cholangiolithiasis patients before operation (P<0.01), and compared to the control group, it obviously raised after YCDDD treatment (P<0.01), the same happened in the cholangiolithiasis patients. The value of TXA 2 and PGI 2 in the bile was obviously higher (P<0.01, P<0.05) in cholangitis patients than those in chlangiolithiasis, and obviously reduced after YCDDD administration (P<0.01). The level of FN in the treated group and the level of biliary TXA 2 and PGI 2 in rabbits with cholangitis were significantly higher than those in the control group (P<0.01). Conclusion: YCDDD caused the increase of FN and decrease of biliary TXA 2 and PGI 2 , which might be one of the mechanisms of the drug carried out in cholangitis patients.

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