复方参地汤与迪银片联合治疗慢性斑块型银屑病的疗效评价

作者	单位
高炳爱	中国中医研究院广安门医院皮肤性病科!北京100053
许铣	中国中医研究院广安门医院皮肤性病科!北京100053

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中文摘要:

目的 :为探寻一种较好的治疗慢性斑块型银屑病的方法。方法 :采用中药复方参地汤合低剂量迪银片治疗慢性斑块型银屑病 35例 (综合组 ) ,同时与单纯服复方参地汤治疗的 2 5例 (中药组 )及单纯服迪银片治疗的 18例 (西药组 )作对照观察。结果 :总有效率综合组为 94 2 9% ,中药组、西药组分别为88 0 0 %、83 33% ;显效率综合组为 62 86% ,中药组、西药组分别为 36 0 0 %、2 7 78%。经Ridit检验 ,3组疗效差异有显著性 (P <0 0 5) ,经 χ2 检验 ,3组总有效率差异无显著性 ,但显效率差异有显著性。并对综合组 11例患者分别于治疗前后检测血清IL 8及血浆内皮素水平 ,结果治疗后较治疗前显著降低。结论 :复方参地汤与迪银片联合应用治疗斑块型银屑病 ,其疗效优于单纯用复方参地汤或单纯用迪银片。

英文摘要:

To seek for a better therapy for chronic plaque type psoriasis. Methods: The effect of 35 patients in the tested group treated with combination therapy of composite Shendi Decoction (CSDD) and Diyin Tablet (DYT) was observed and compared with the effect of those treated by CSDD alone (25 cases )or by DYT alone (18 cases ) as the control groups. Results: The total effective rate in the treated group was 94.29%, and that in the two control groups was 88 00% and 83.33% respectively. The markedly effective rate in the treated group was 62.86%, and that for the control groups was 36 00% and 27.78% respectively. Ridit test showed significant difference among the effectiveness in the three groups, while χ 2 showed the difference of the total effective rate in the three groups was insignificant, but that of the markedly effective rate was significant. Serum IL-8 and plasma endothelin levels of 11 cases in the treated group were examined before and after treatment, the results showed that both the two parameters were reduced after the combination therapy. Conclusion: The effect of combination therapy of CSDD and DYT was better than that of CSDD or DYT alone, therefore, it is worth further studying and spreading.

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