盛梅笑,李惊子,王海燕,屈磊,许远,邹万忠,洪健美.黄芪当归对急性缺血再灌注大鼠肾损伤的治疗作用[J].中国中西医结合杂志,2001,(1):43-46 |
黄芪当归对急性缺血再灌注大鼠肾损伤的治疗作用 |
Therapeutic Effect of Astragalus and Angelica on Renal Injury Induced by Ischemia/Reperfusion in Rats |
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DOI: |
中文关键词: 黄芪 当归 缺血再灌注 肾功能 |
英文关键词:Astragalus Angelica ischemia/reperfusion renal function |
基金项目:国家自然科学基金资助课题! (No .39970 92 9) |
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中文摘要: |
目的 :观察黄芪、当归对急性肾损伤的影响。方法 :采用双侧肾动脉夹闭 4 5min的缺血再灌注损伤大鼠模型 ,观察缺血再灌注前后肾小球滤过率 (GFR)、肾血浆流量 (RPF)、钠排泄分数 (FENa)、尿量、平均动脉压的变化 ,以及肾组织形态学的改变。结果 :黄芪、当归可促进再灌注后GFR及RPF的恢复 ,避免缺血后少尿的发生或使少尿期缩短 ,减轻FENa升高的幅度 ,并能改善肾组织病理损伤。结论 :黄芪、当归对急性肾损伤具有一定保护作用 |
英文摘要: |
To observe the effect of Astragalus and Angelica on acute renal injury. Methods: Using the ischemia/reperfusion model established by blocking blood flow through clamping of bilateral renal artery for 45 min, the changes of glomerular filtration rate (GFR), renal plasma flow (RPF), fractional excretion of sodium (FENa), urinary volume (UV) and mean arterial pressure (MAP) as well as the morphological change of kidney before and after ischemia/reperfusion were observed. Results: Astragalus and Angelica could promote recovery of RPF and GFR after ischemia/reperfusion, prevent the oliguria or shorten the oliguria period, reduce the increment of FENa and improve the histomorphological injury of kidney. Conclusion: Astragalus and Angelica have certain effect in protecting kidney from acute renal injury. |
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