| 虞荣喜,周郁鸿,朱宁希,沈建平,胡致平,罗秀素,林圣云,沈一平,陈均法,孙洁.造血干细胞移植联合中医中药治疗恶性血液病12例[J].中国中西医结合杂志,2001,(2):90-93 |
| 造血干细胞移植联合中医中药治疗恶性血液病12例 |
| Twelve Cases of Malignant Hematopathy Treated by Combined Therapy of Hematopoietic Stem Cell Transplantation and Chinese Herbal Medicine |
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| DOI： |
| 中文关键词: 白血病 淋巴瘤 造血干细胞移植 中医中药 |
| 英文关键词:leukemia lymphoma hematopoietic stem cells transplantation Chinese herbal medicine |
| 基金项目:浙江省中医管理局资助课题!(No .940 9) |
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| 中文摘要: |
| 目的 :评价造血干细胞移植联合中医中药治疗恶性血液病的疗效。方法 :采用异基因骨髓和外周血干细胞移植治疗慢性粒细胞 (慢粒 )白血病 4例 (慢性期 3期 ,加速期 1例 )和急非淋白血病 1例 ;用自体骨髓和外周血干细胞移植 7例 ,包括急非淋白血病 5例 (CR13例 ,CR2 2例 )和恶性淋巴瘤 2例 (初发 1例 ,复发 1例 )。预处理方案 :异基因者采用全身60 Co照射加环磷酰胺 (TBI加Cy)或马利兰加环磷酰胺 (Bu+Cy) ,自体移植者采用MAC(马法兰 +阿糖胞苷 +环磷酰胺 )或MAC +乙叉鬼臼甙 (VP16)。移植后根据患者辨证论治 ,给予中药口服。结果 :12例移植均获成功 ,重建造血 ,中位随访时间 18( 4～ 70 )个月 ,移植相关死亡率 8 3% ( 1/12例 ) ,移植后复发和慢粒急变率 2 5% ( 3/12例 ) ,无病长期生存率 66 7% ( 8/12例 )。按急性白血病CR1和慢粒白血病慢性期计算总有效率 88 8% ( 8/9例 )。结论 :急性白血病患者如无相配的骨髓供者 ,在CR1期进行自体骨髓或外周血干细胞移植可降低急性白血病的复发率 ;慢粒白血病在慢性期进行异基因骨髓或外周血干细胞移植 ,可以达到长期存活 ;恶性血液病在移植后服用中药有可能降低并发症 ,并对促进造血恢复起到一定的作用 |
| 英文摘要: |
| Objective: To evaluate the effect of hematopoietic stem cell transplantation combined with Chinese herbal medicine in treating malignant hematopathy. Methods: Allo bone marrow transplantation (Allo BMT) or allo peripheral blood stem cell transplantation (Allo-PBSCT), with conditioning regimen of TBI+Cy or Bu +Cy, was used to treat 4 cases of chronic granulocytic leukemia (CGL, 3 of chronic phase and 1 of acceleration phase) and one case of acute non lymphocytic leukemia (ANLL). And auto BMT or auto PBSCT, with conditioning regimen of MAC or MAC+VP16, was used to treat 7 cases of hematopathy, including 5 cases of ANLL (3 of CR 1 and 2 of CR 2) and 2 cases of malignant lymphoma (1 of first occurring and 1 of relapse). Chinese herbal medicine was given orally to all the 12 patients after transplantation according to TCM Syndrome Differentiation. Results: All patients were successfully engrafted. Within the median follow up period of 18 (4-70) months, one patient (8 3%) died of transplantation related death, 3(25 0%) relapsed and 8 (66 7%) survived free of original disease. The transplantation effective rate was 88 8% as counting by ANLL CR 1 and CGL chronic phase. Conclusion: Auto BMT or auto PBSCT in CR 1 stage of acute leukemia could reduce the relapse rate, when there was no matched bone marrow donor; allo BMT or allo PBSCT in chronic stage could result in long term disease free survival of patients; Chinese herbal medicine administration in patients of malignant hematopathy might reduce the complications and plays certain role in promoting recovery of hematopoietic function. |
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