| 杨胜,张永祥,吕晓东,乔善义,董剑英,赵毅民.六味地黄汤活性部位3A的免疫调节作用机理研究[J].中国中西医结合杂志,2001,(2):119-122 |
| 六味地黄汤活性部位3A的免疫调节作用机理研究 |
| Study on Immunomodulating Mechanism of the Active Fraction of Liuwei Dihuang Decoction |
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| DOI： |
| 中文关键词: 六味地黄汤 活性部位 免疫调节 T细胞亚群 IgG γ干扰素 RT-PCR |
| 英文关键词:Liuwei Dihuang Decoction active fraction immuno modulating T lymphocyte subsets immunoglobulin G interferon γ RT polymerase chain reaction |
| 基金项目:国家重点基础研究发展规划项目!(No .G1 9990 5440 1 );“九五”国家攀登计划预选项目资助课题 |
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| 中文摘要: |
| 目的 :对六味地黄汤活性部位 3A的免疫调节作用机理进行初步研究。方法 :观察 3A对环磷酰胺 (Cy)处理小鼠 ,荷瘤小鼠和快速老化小鼠的T细胞亚群 ,B细胞产生IgG水平 ,γ干扰素 (IFN γ)mR NA的表达水平的影响及体外活性研究。结果 :口服给予 3A对 3种模型小鼠脾脏T细胞亚群的变化均具有不同程度的恢复作用 ,并促进快速老化小鼠脾细胞分泌IgG ,提高Cy处理小鼠脾细胞IFN γmRNA的表达水平。结论 :3A对免疫功能的改善作用与调节T、B细胞的比例或改善其功能具有一定的关系 |
| 英文摘要: |
| Objective: To investigate the immunomodulating mechanism of 3A, an active fraction extracted from the ethanol soluble portion of Liuwei Dihuang Decoction (LWDHD). Methods: Influence of 3A on T lymphocyte subsets, IgG production of B cells, interferon γ (IFN γ) mRNA expression in cyclophosphamide (Cy) treated mice, tumor bearing mice and senescence accelerated mouse prone/8 (SAMP8) were assessed in vivo and in vitro. Results: Oral administration of 3A could elevate the decreased T lymphocyte subsets in all model mice, it also could promote the IgG secretion of splenic cells in SAMP8 and increase IFN γ mRNA expression in Cy treated mice. Conclusion: The immunomodulating effect of 3A is related with its effects in regulating ratio of T and B cells or in improving their functions. |
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