肝豆片Ⅰ号对肝豆状核变性患者胆汁微量元素影响的前瞻性研究

目的 :观察中药肝豆片Ⅰ号对肝豆状核变性 (HLD)患者胆汁微量元素的影响。方法 :3 2例HLD患者口服肝豆片Ⅰ号治疗 4周 ,采用十二指肠引流术留取治疗前后HLD患者的胆汁B液 ,并与非HLD患者 3 0例胆汁作为对照组。运用原子吸收分光光度计分别测定两组患者胆汁中铜、锌、铁、钙等元素的含量。结果 :治疗前HLD患者胆汁中铜、铁含量及铜 /锌比值显著低于非HLD对照组 (P <0 0 1或P <0 0 5) ,钙含量显著高于非HLD对照组 (P <0 0 1) ,而锌含量两组差异无显著性 ;治疗后治疗组胆汁排铜量较治疗前显著增加 (P <0 0 5) ,而锌、铁、钙含量及铜 /锌比值无明显变化。结论 :胆汁排铜障碍是导致HLD患者体内铜蓄积的机制之一 ,肝豆片Ⅰ号能促进HLD患者胆汁排铜

英文摘要:

To observe the effect of Gandou tablet I (GDI), a Chinese herbal recipe, on the content of biliary trace elements in hepatolenticular degeneration (HLD) patients. Methods: Before and after 4 weeks treatment by oral taken GDI, bile of 32 cases of HLD were collected by duodenal drainage for determining biliary trace elements, including copper, zinc, iron and calcium, by spectrophotometer of atom absorption spectrum, and compared with those of 30 cases of non HLD patients as the control. Results: The contents of copper, iron and copper/zinc ratio were obviously lower, while the content of calcium greatly higher (P<0 01), in the HLD group before GDI treatment than those in the control (P<0 01 or P<0 05), but the content of zinc was not significantly different between the two groups. The output of biliary copper after GDI treatment was significantly increased compared with that before treatment (P<0 05), but the contents of zinc, iron, calcium and copper/ zinc ratio were not markedly changed. Conclusion: The impediment to output of biliary copper was one of the mechanisms for copper storage in body of HLD patients. GDI could promote excretion of biliary copper in the HLD patients.

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