健脾益气化湿中药对慢性萎缩性胃炎表皮生长因子水平的影响

Study on Effect of Spleen Invigorating, Qi Benefiting and Dampness Removing Chinese Drugs and Western Medicine on Serum Epidermal Growth Factor in Chronic Atrophic Gastritis Patients

免费下载全文查看/发表评论下载PDF阅读器

DOI：

中文关键词: 慢性萎缩性胃炎健脾益气化湿表皮生长因子

英文关键词:chronic atrophic gastritis invigorating Spleen Qi benefiting removing Dampness epidermal growth factor

基金项目:

作者	单位
孙蕾民	浙江大学医学院附属邵逸夫医院
乔樵	浙江中医学院附属医院
姒健敏	浙江大学医学院附属邵逸夫医院
戴宁	浙江大学医学院附属邵逸夫医院
周亨德	浙江中医学院附属医院
朱曙东	浙江大学医学院附属邵逸夫医院

摘要点击次数: 1657

全文下载次数: 1462

中文摘要:

目的 :探讨健脾益气化湿中药及西药对慢性萎缩性胃炎 (CAG)患者表皮生长因子 (EGF)水平的影响。方法 :经中医辨证论治分为健脾 1组、健脾 2组、化湿组、西药组和正常对照组 (简称对照组 ) ,并进行相应的治疗 ,检测各组治疗前后血清EGF水平变化 ,并作疗效对比分析。结果 :CAG各组治疗前血清EGF均明显高于对照组 (P <0 0 1) ,治疗后健脾 1、2组临床症状和病理变化明显改善 (P <0 0 1) ,两健脾组血清EGF含量也明显下降 (P <0 0 5) ,化湿组治疗后血清EGF上升 (P <0 0 5) ,西药组治疗后血清EGF变化不大。结论 :CAG炎症刺激可导致血清EGF反应性升高 ,经中药治疗后EGF水平回复 ;检测EGF可作为CAG转归观察的敏感指标

英文摘要:

To investigate the effect of various combinations of Spleen invigorating and Dampness removing recipes and western medicine on level of serum epidermal growth factor (sEGF) in patients of chronic atrophic gastritis (CAG). Methods: By means of Syndrome Differentiation three groups were divided as (1) Spleen invigorating I group (SI I); (2) Spleen invigorating Ⅱ group (SI Ⅱ); (3) Dampness removing group (DR); (4) western medicine group (WM); (5) healthy volunteers served as normal control group. The changes of symptoms and sEGF level were determined and compared between groups as well as before and after treatment. Results: The sEGF in various groups of CAG were higher than that in the normal control (P<0 01). In patients of SI Ⅰ and Ⅱ groups, symptoms and pathological manifestations were improved significantly (P<0 01), and sEGF dropped markedly after treatment (P<0 01 and P<0 05). The level of sEGF in DR raised after treatment (P<0 05), but the level of sEGF in WM group lowered insignificantly. Conclusion: Inflammation of gastric mucosa could cause responsive elevation of sEGF in CAG patients. After treated with Spleen invigorating and Dampness removing Chinese drugs, the symptoms of CAG improved, simultaneously with the restoration of sEGF. sEGF could be taken as a sensitive index of the prognosis of CAG.

关闭