百岁方口服液治疗血管性痴呆的临床观察

作者	单位
夏翔	上海第二医科大学附属瑞金医院!上海200025
沈小珩	上海第二医科大学附属瑞金医院!上海200025
柳玉瑾	上海第二医科大学附属瑞金医院!上海200025
邰杏芳	上海第二医科大学附属瑞金医院!上海200025
戴云	上海第二医科大学附属瑞金医院!上海200025
张一波	上海第二医科大学附属瑞金医院!上海200025

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中文摘要:

目的 :探讨百岁方口服液治疗血管性痴呆 (VD)的疗效。方法 :将符合美国精神病学会DSM IV诊断标准的VD患者 ,按随机数字表分为治疗组 37例 ,对照组 2 8例 ,分别采用百岁方口服液及脑复康治疗 ,疗程 3个月。观察治疗前后患者的临床症状、中医证候变化 ,以及简易智力状态速检表 (MMSE)和日常生活能力量表 (ADL)积分的改变 ,血液流变学、血小板聚集试验、血脂分析等项指标。结果 :临床观察表明百岁方口服液能改善临床症状和中医证候 ,降低血脂 ,改善血液流变性 ,提高患者多种智力量表积分。治疗组显效率 2 4 32 % ,总有效率 75 6 8% ,对照组分别为 10 71% ,6 0 71% ;两组间差异有显著性 (P <0 0 1)。结论 :百岁方口服液能够促进学习记忆的恢复和改善临床症状 ,是治疗血管性痴呆的有效中药制剂。

英文摘要:

Objective: To study the effect of Baisuifang Oral Liquid (BSF) in treating vascular dementia. Methods: Patients selected according to the diagnostic standard of American Association of Psychiatry were randomly divided into two groups, the 37 patients in the BSF treated group and the 28 patients in the control group treated by Naofukang with therapeutic course of 3 months. Changes of clinical symptoms, TCM Syndrome, mini-mental state examination (MMSE) and activity of daily living (ADL) score, hemorrheologic characters, platelet aggregation and blood lipid were observed. Results: BSF could ameliorate the symptoms and TCM Syndrome, decrease blood lipid, improve the hemorrheologic character, elevate the MMSE and ADL score of patients. The total effective rate in the treated group was 75.68% and the markedly effective rate 24.32%, which were obviously superior to those in the control group respectively. Conclusion: BSF is an effective Chinese herbal preparation in treating vascular dementia, which could promote the restoration of learning memory, and improve the clinical symptoms.

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