急性过敏性紫癜免疫功能的改变及中西医结合治疗对其调节作用

Immune Functional Changes in Patients of Acute Henoch-Schonlein Purpura and Regulatory Effect of Integrated Traditional Chinese and Western Medicine on It

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中文关键词: 过敏性紫癜免疫功能中药转移因子

英文关键词:Henoch-Schonlein purpura immune function Chinese herbal medicine transfer factor

基金项目:河北省张家口市科委科研基金资助 (No.991 1 2 1 )

作者	单位
贾文翠	河北省张家口医学院第一附属医院
张有成	河北省张家口医学院第一附属医院
魏阿平	河北省张家口医学院第一附属医院
梁桂珍	河北省张家口医学院第一附属医院
郭卫平	河北省张家口医学院第一附属医院
郜贺荣	河北省张家口医学院第一附属医院
张玉芬	河北省张家口医学院第一附属医院
张英茹	河北省张家口医学院第一附属医院

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中文摘要:

目的 :观察急性过敏性紫癜 (HSP)患儿免疫功能的改变 ,采用中西医结合治疗的方法 ,探讨中药银浮汤加转移因子对急性HSP患儿免疫功能的调节作用。方法 :观察组 (35例 )采用中药银浮汤加转移因子治疗 ,并与采用常规治疗的对照组 (35例 )比较。治疗前后进行IgG、IgA、IgM、CD3、CD4 、CD8、CD4 /CD8比值、红细胞C3b受体花环率及免疫复合物花环率的检测。同时与 4 0名健康儿童作健康对照 ,观察治疗前后免疫指标的变化。结果 :治疗前 (急性期 )与健康对照组比较 ,IgA、IgM、CD4 、CD4 /CD8比值 ,红细胞C3b受体花环率均明显升高 ,而CD8明显下降 ,差异均有显著性 (P <0 0 1)。观察组与对照组治疗前后免疫指标的比较差异亦有显著性 (P <0 0 1) ,而观察组更优于对照组 (P <0 0 5)。观察组愈显率与对照组比较差异亦有显著性 (P <0 0 1)。结论 :急性HSP存在多种免疫功能的改变 ,中药银浮汤加转移因子治疗 ,具有明显调节免疫功能的作用 ,是一种副作用少 ,复发率低 ,疗效显著的治疗方法

英文摘要:

Objective: To observe the changes of immune function in children with acute Henoch-Schonlein purpura (AHSP) and the effects of integrated traditional Chinese and western medicine (TCM-WM) on it. Methods: Immunological criteria in TCM-WM group (n=35) treated by Yinfu Decoction (YFD) combined with transfer factor and 35 patients in the control group (n=35) treated by conventional treatment were observed and compared before and after treatment. Also the criteria were compared with those of 40 healthy subjects. Results: Before treatment, the levels of IgA, IgM, CD 4, CD 4/CD 8 ratio, rosette forming rate of RBC-C 3b receptor in patients were higher than those in the healthy subjects, but the levels of CD 8 was obviously lower, the difference was significant (P<0.01). The above-mentioned criteria were all improved in the two treated groups after treatment, and the improvement was more significant in the TCM-WM group than that in the control group (P<0.05). Besides, the cure-markedly effective rate in the former was better than that in the latter significantly (P<0.01). Conclusion: There exist multiple immune functional disturbance in AHSP patients. Combined treatment of YFD and transfer factor has obvious immune regulatory effect and is an effective therapy with few side-effects and low recurrence rate.

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