化呆醒神汤对大鼠血管性痴呆模型SS、AVP含量及SSmRNA表达的影响

Effect of Huadai Xingshen Decoction on Cerebral Somatostatin, Arginine Vasopressin and Somatostatin mRNA Expression in Vascular Dementia Rat Model

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DOI：

中文关键词: 化呆醒神汤血管性痴呆神经肽原位杂交

英文关键词:Huadai Xingshen Decoction vascular dementia neuropeptide in situ hybridization

基金项目:

作者	单位
张力	北京中医药大学
王洪图	中国医药科技出版社

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中文摘要:

目的 :为了探讨化呆醒神汤治疗血管性痴呆的作用机制。方法 :采用反复缺血再灌注方法复制血管性痴呆 (VD)动物模型 ,以具有调理脾胃、消痰化瘀功效的化呆醒神汤进行治疗 ,并以喜得镇作为阳性对照。结果 :VD大鼠海马和皮层内脑内生长抑素 (SS)、精氨酸加压素 (AVP)含量均显著减少 ,额叶皮质内SSmRNA表达强度明显下降 ,化呆醒神汤对VD大鼠海马内SS、AVP含量及额叶皮质内SSmRNA表达强度有明显的上调作用 ,且对SS含量及SSmRNA表达强度的上调作用优于对照组。结论 :化呆醒神汤通过提高前体mRNA的合成能力并增加AVP含量 ,增加神经营养作用 ,促进受损神经元功能的恢复 ,从而改善VD大鼠的智能障碍。

英文摘要:

Objective: To study the mechanism of Huadai Xingshen Decoction (HDXSD) in treating vascular dementia (VD). Methods: Rat model of VD was established by repeated ischemia/reperfusion and treated with HDXSD. Hydergine was taken for positive control. The content of somatostatin (SS), arginine vasopressin (AVP) and SS mRNA expression model rat′s cortex and hippocampus were observed. Results: The SS and AVP contents of cortex and hippocampus in model rats were decreased significantly, and the SSmRNA expression in cortex of frontal lobe reduced, too. HDXSD showed an up-regulation on the above-mentioned parameters, and the effect on SS cortex and SS mRNA expression was higher than that of hydergine. Conclusion: HDXSD improves intellectual impairment of VD rats by increasing the synthetic ability of SSmRNA and content of AVP, which in turn improve the neurotrophic effect and promote the restoring function of injured neuron.

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