托里消毒散对手术前后肝癌患者细胞免疫功能的影响

作者	单位
黎洪浩	中山医科大学孙逸仙纪念医院广州510120
梁俊雄	中山医科大学孙逸仙纪念医院广州510120
陈积圣	中山医科大学孙逸仙纪念医院广州510120

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中文摘要:

目的 :探讨托里消毒散对调节肝癌患者细胞免疫功能的作用。方法 :选择可手术切除的肝癌患者 38例 ,随机分两组。Ⅰ组 :2 0例 ,在肝癌切除术前和术后第 7天服用中药托里消毒散 ,服药前后检测T淋巴细胞亚群 (CD3、CD4 、CD8)和肝功能〔谷草转氨酶 (AST)、谷丙转氨酶 (ALT)、直接胆红素 (DBIL)、间接胆红素 (IBIL)〕 ;Ⅱ组 :18例 ,不服用托里消毒散 ,在与Ⅰ组相应的时期检测T淋巴细胞亚群和肝功能。T淋巴细胞亚群的测定采用单克隆抗体标记直接免疫花环法。结果 :Ⅰ组患者CD3、CD4 、CD4 /CD8显著升高 ,术后AST、ALT、DBIL、IBIL降低 ;Ⅱ组无明显变化。结论 :肝癌切除术前和术后服用托里消毒散均可提高患者的细胞免疫功能 ,术后服用还可明显改善患者的肝功能。

英文摘要:

To explore the regulatory effect of Tuoli Xiaodu Powder (TLXDP) on cell mediated immunofunction (T lymphocytes subsets) in liver carcinoma patients. Methods: Thirty eight patients with operable liver carcinoma were divided randomly into 2 groups. TLXDP was given to the 20 cases in Group Ⅰ before and 7 days after surgical operation, but not given to the 18 cases in Group Ⅱ. T lymphocyte subsets (CD 3, CD 4 and CD 8 by monoclonal antibody labelled direct immune rosette method) and liver function, aspartate aminotransferase (AST), alanine transaminase (ALT), direct and indirect bilirubin (DBIL and IBIL) were determined before and after treatment. Results: T lymphocyte subsets elevated and liver function enhanced significantly in Group Ⅰ after treatment, but unchanged in Group Ⅱ. Conclusion: Administration of TLXDP before and after surgical operation could enhance the cell mediated immunofunction and improve the liver function significantly in patients with liver carcinoma.

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