新正天丸对偏头痛患者血小板膜粘附分子表达的影响

作者	单位
朱成全	第一军医大学南方医院中医科广州510515
谢炜	第一军医大学南方医院中医科广州510515
陈宝田	第一军医大学南方医院中医科广州510515

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中文摘要:

目的 :研究新正天丸对偏头痛患者血小板膜粘附分子表达的影响。方法 :将 68例患者分为两组 ,治疗组 (35例 )口服新正天丸 ,对照组 (33例 )口服氟桂嗪胶囊 ,疗程均为 30天。应用流式细胞仪检测患者治疗前后全血血小板膜粘附分子GPⅡb/Ⅲa(CD4 1)和P 选择素 (CD62 P) ,并与健康人作对照。结果 :治疗组疗效 (显效率和总有效率 )优于对照组 (P <0 0 5和P <0 0 1)。偏头痛患者发作期、间隙期血小板膜粘附分子表达均较健康人为高 (P <0 0 1) ,而新正天丸能明显降低其表达 (P <0 0 1)。结论 :新正天丸可降低血小板膜粘附分子的表达 ,并能抑制血小板的活化

英文摘要:

Objective: To investigate the effect of New Zhengtian Pill (NZTP) on expression of whole blood platelet membrane adhesion molecules (PMAM) in patients of migraine. Methods: Sixty eight patients were divided into two groups, the 35 patients in the treated group treated by NZTP orally and the 33 patients in the control group treated by Fuguiqin Capsule with a therapeutic course of 30 days for both groups. Changes of PMAM GPⅡb/Ⅲa(CD 41 ) and P selectin (CD 62 P) were observed by flow cytometry and compared with those in healthy persons. Results: The markedly effective rate and total effective rate in the treated group was higher than those in the control group respectively (P<0 05 and P<0 01). The PMAM expression was also higher in patients, both at onset stage and intermittent stage, than in healthy persons (P<0 01), NZTP treatment could reduce their increased expression significantly (P<0 01). Conclusion: NZTP could reduce the PMAM expression and inhibit the activation of platelet.

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