温筋通对链脲佐菌素糖尿病大鼠血糖及坐骨神经终末期糖基化终产物的影响

作者	单位
郭赛珊	中国医学科学院中国协和医科大学北京协和医院中医科
唐代屹	中国医学科学院中国协和医科大学北京协和医院中医科
梁晓春	中国医学科学院中国协和医科大学北京协和医院中医科
张建伟	中国医学科学院中国协和医科大学基础研究所病理生理研究室
孙仁宇	中国医学科学院中国协和医科大学基础研究所病理生理研究室
张宏	中国医学科学院中国协和医科大学基础研究所病理生理研究室

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中文摘要:

目的 :观察中药复方温筋通对糖尿病大鼠血糖、坐骨神经终末期糖基化终产物的影响。方法 :采用链脲佐菌素糖尿病大鼠模型 ,随机分为预防组和治疗组 ,给予温筋通灌胃 ,并以氨基胍作为对照 ,治疗 12周 ,观察温筋通对糖尿病大鼠血糖和坐骨神经终末期糖基化终产物的影响。结果 :温筋通预防组和治疗组血糖、温筋通预防组和氨基胍组坐骨神经终末期糖基化终产物 ,均较模型组为低 (P <0 0 1) ;氨基胍组血糖高于温筋通预防组 (P <0 0 5 ) ,与模型组比较 ,差异无显著性 (P >0 0 5 )。结论 :温筋通可能通过降低血糖、抑制终末期糖基化终产物在神经组织中的形成 ,从而预防糖尿病周围神经病变

英文摘要:

To investigate the effect of Wenjingtong Comp os ita (WJTC) on blood glucose and advanced glycosylation end products (AGEs) in sc iatic nerve of streptozotocin (STZ) induced diabetic rats. Methods: STZ induced diabetic rats were randomized to WJTC p revention group and WJTC treatment group. The levels of blood glucose and AGEs i n s ciatic nerve of the animals were checked after 12 weeks′ treatment and compared with that of aminoguanidine (AG) treatment group. Results: Blood glucose level in the WJTC prevention and treatm ent group, and AGEs in sciatic nerve of the WJTC prevention group and the AG gro up were lower than those of the non treated group (P<0 01). B lood g lucose level in the AG group was higher than that in the WJTC prevention group ( P<0 05), but was not significantly different from that in the non treated group (P>0 05). Conclusion: WJTC might prevent diabetic peripheral neuropathy by decreasing blood glucose and inhibiting AGEs formation in sciatic nerve in ST Z induced diabetic rats.

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