冬虫夏草和青蒿素抑制狼疮性肾炎复发的研究

目的 :观察冬虫夏草 (简称虫草 )和青蒿素抑制狼疮性肾炎复发的作用。方法 :6 1例经用激素及环磷酰胺冲击治疗已无狼疮活动的狼疮性肾炎患者 ,随机分为两组 ,治疗组 (31例 )予虫草粉每日 3～4 g ,分 3次空腹口服 ;青蒿素粉每日 0 6 g ,分 3次餐后口服 ,连续服用 3年。对照组 (30例 )口服雷公藤多甙片和 (或 )保肾康片等药物治疗。两组均连续观察 5年 ,监测血肌酐、肌酐清除率、抗核抗体等实验室有关指标及有否狼疮活动的临床表现。结果 :治疗组显效 2 6例 (83 9% ) ,有效 4例 (12 9% ) ,无效 1例 (3 2 % ) ;对照组显效 15例 (5 0 0 % ) ,有效 8例 (2 6 7% ) ,无效 7例 (2 3 3% ) ,两组显效率比较差异有显著性 (P <0 0 1)。治疗组补体C3持续稳定在 (1 2 1± 0 2 0 )g/L正常水平 ,肌酐清除率治疗前后比较差异无显著性 ,与对照组比较差异有显著性 ;治疗组同时减少了药物本身的不良反应。结论 :冬虫夏草和青蒿素可以抑制狼疮肾炎的复发 ,保护肾功能。

英文摘要:

Objective: To observe the effect of Cordyceps sinensis and artemisinin in preventing recurrence of lupus nephritis (LN). Methods: Sixty one LN patients, who had no activities by corticosterone and cyclophosphamide (CTX) impacting therapy were randomly divided into two groups. The 31 cases in the treated group were given Cordyceps powder 2～4 g/d before meal and artemisinin 0.6 g/d after meal in three portions orally taken for 3 years. The 30 patients in the control group were treated with tripterygiitotorum and/or Baoshenkang tablet. The consecutive observation lasted for 5 years to monitor the clinical manifestations of lupus and laboratory indexes including blood creatinine, creatinine clearance rate (CCr) and antinuclear antibodies (ANA). Results: The therapeutic effect showed markedly effective in 26 cases (83.9%), effective in 4 (12.9%) and ineffective in 1 (3.2%) in the treated group, while in the control group, the corresponding numbers were 15 (50.0%), 8 (26.7%) and 7 (23.3%), the difference between the two groups in markedly effective rate was significant (P<0 01). In the treated group, C 3 level was stabilized at above 1.21±0.20g/L, which was over the normal range, CCr was unchanged as compared before and after treatment, which was significantly different from that in the control group. Moreover, the side effects occurred in the treated group was less. Conclusion: Cordyceps and artemisinin could prevent the recurrence of LN and protect kidney function.

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