糖尿病缺血性中风中脏腑、中经络证候与高凝血症及胰岛素抵抗关系的研究

Study on Stroke Syndrome of Chinese Medicine and Its Relationship with Blood Hypercoagulative Status and Insulin Resistance in Diabetic Ischemic Stroke Patients

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中文关键词: 糖尿病　缺血性中风病类证候胰岛素抵抗高凝血症

英文关键词:diabetes mellitus ischemic stroke TCM Syndrome insulin resistance blood hypercoagulative state

基金项目:广州中医药大学科研课题 (No .980 0 1 )

作者	单位
李创鹏	广州中医药大学附属珠海市中医院神经内分泌专科广东519015
谌剑飞	广州中医药大学附属珠海市中医院神经内分泌专科广东519015
彭敏	广州中医药大学附属珠海市中医院神经内分泌专科广东519015
张艳玲	广州中医药大学附属珠海市中医院神经内分泌专科广东519015

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中文摘要:

目的 :探讨糖尿病缺血性中风中脏腑、中经络证候与高凝血症及胰岛素抵抗的关系。方法 :采用能反映胰岛素抵抗结果的胰岛素敏感指数 (ISI)与血高凝状态水平的血小板聚集率 (PAgT)、纤维蛋白原 (FG)、体外血栓长度 (VTL)及活化部分凝血酶原时间 (APTT)来论证中风病证候与其之间的相互联系。结果 :中脏腑组中 ,风证、痰湿证、火热证及阴虚阳亢证证候评分值及PAgT、VTL、FG等测定值均高于中经络组 (P <0 0 5或P <0 0 1) ,而其ISI值则显著低于中经络组 (P <0 0 1)。结论 :本病中脏腑及中经络证候与胰岛素抵抗及高凝血症有密切关系。

英文摘要:

Objective: To study the relationship of TCM Syndromes, involving Viscera Syndrome and involving Meridian Syndrome, with blood hypercoagulative state and insulin resistance in patients with diabetic ischemic stroke. Methods: Insulin sensitivity index (ISI) could reflect the insulin resistance, and those reflecting blood hypercoagulative state parameters such as platelet agglutination test (PAgT), fibrinogen (FG), in vitro thrombus length (VTL) and activating partial thrombinogen time (APTT), were used to expound and prove the relationship with the stroke syndrome. Results: The symptom scores, PAgT, VTL, FG levels in patients involved with Viscera Syndromes (including those of Wind Syndrome, Phlegm Dampness Syndrome, Heat Fire Syndrome and Yin deficiency with Yang excess Syndrome) were significantly higher than those in patients involved with Meridian Syndromes (P<0 05 or P<0 01), while the ISI level in the former was lower than that in the latter (P<0 01). Conclusion: There is close relationship between blood hypercoagulative state, insulin resistance and TCM Stroke Syndromes in patients with diabetic ischemic stroke.

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