降铅冲剂治疗儿童注意缺陷多动障碍的临床观察

作者	单位
陈健	浙江省中医院儿科杭州310006
陈玉燕	浙江省中医院儿科杭州310006
王晓鸣	浙江省中医院儿科杭州310006
宣桂琪	浙江省中医院儿科杭州310006

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中文摘要:

目的 :观察降铅冲剂治疗儿童注意缺陷多动障碍 (attentiondeficithyperactivitydisorder,ADHD)的临床疗效及作用机制。方法 :将 80例ADHD患儿随机分为降铅组及利他林组 ,于治疗前及治疗后3个月分别测评血铅浓度及多动指数量表 (Conners)分值 ,并观察临床疗效。同时设 6 0名健康儿童为对照组 ,同时测评血铅浓度及Conners分值。结果 :(1)降铅组总有效率为 92 5 % ,利他林组总有效率为 72 5 % ,两组比较 ,差异有显著性 (χ2 =5 5 4,P <0 0 5 )。 (2 )ADHD患儿血铅浓度及Conners分值明显高于健康儿童(P <0 0 1)。治疗后两组血铅浓度及Conners分值均下降 ,且降铅组与利他林组比较差异有显著性 (P <0 0 5 ,P <0 0 1)。结论 :ADHD患儿存在高血铅 ,降铅冲剂通过降血铅而提高临床疗效。

英文摘要:

Objective: To explore the effect of Jiangqian granule (JQG) in treating children attention deficit hyperactivity disorder (ADHD) and its mechanism. Methods: Eighty children with ADHD were randomly divided into two groups, the treated group treated with JQG and the control group treated with Ritalin. Blood lead concentration and Conners′ scoring were measured before and after 3 months treatment and the therapeutic effects were assessed. Besides, blood lead concentration and Conners′ scoring in 60 healthy children were also determined for control. Results: The total effective rate in the treated group and the control group was 92.5% and 72.5% respectively, significant difference existed between the two groups. Blood lead level and Conners′ scores in ADHD patients were significantly higher than those in the healthy control (P<0 01). The two parameters decreased after treatment in both groups, but the lowering was more significant in the treated group (P<0 05, P<0 01). Conclusion: Blood lead concentration raised in ADHD patients, JQG could enhance the clinical therapeutic effect by means of reducing the blood lead.

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