氧化苦参碱治疗慢性乙型病毒性肝炎疗效及其与HBV负荷的关系探讨

作者	单位
陈燕熙	江苏省海门市卫生防疫站
茅佰元	江苏省海门市卫生防疫站
江建华	江苏省海门市卫生防疫站
施建华	江苏省海门市卫生防疫站
李继强	上海第二医科大学附属仁济医院上海市消化疾病研究所

摘要点击次数: 1201

全文下载次数: 1349

中文摘要:

目的 :研究氧化苦参碱治疗慢性乙型病毒性肝炎疗效及其与HBV负荷的关系。方法 :4 4例慢性乙型肝炎患者 ,随机分为治疗组 (给予氧化苦参碱和一般护肝药物 ) 2 3例 ,对照组 (仅给予一般护肝药物 ) 2 1例。以聚合酶链反应 (PCR)法定量测定血清HBV水平 ,分析不同疗效与不同血清HBV负荷的关系。结果 :氧化苦参碱肌肉注射慢性乙型肝炎 3个月 (0 4g/d) ,HBVDNA及HBeAg转阴率均为 4 3 4 7% ,明显优于对照组 (P <0 0 5 )。治疗后HBVDNA定量水平从 10 6 83± 1 2 7copy/ml降至 10 3 35± 3 0 8copy/ml,治疗后HBeAg转阴的患者 ,其治疗前血清HBVDNA定量水平 (10 6 30± 1 4 2 copy/ml) ,明显低于未转阴者 (10 7 2 3± 1 2 3copy/ml)。结论 :氧化苦参碱治疗慢性乙型肝炎有效 ,治疗前血清HBVDNA水平较低者疗效较好。

英文摘要:

Objective: To study the relationship between serum load level of HBV DNA and therapeutic effect of oxymatrine in patients with chronic hepatitis B. Methods: Forty four patients of chronic hepatitis B were divided into two groups, the treated group was treated with oxymatrine 0.4 g/d by intramuscular injection for 3 months, the control group was treated with some liver protecting agents to estimate the therapeutic effect. The serum level of HBV DNA was determined by quantitative polymerase chain reaction (PCR) before and after treatment. Results: The seroconversion rate of HBV DNA and HBeAg in the treated group was 43.47% and 43.47% respectively, which was obviously better than those in the control group respectively(P<0 05), the quantity of HBV DNA decreased after treatment from 10 6 83±1 27 copy/ml to 10 3 35±3 08 copy/ml. Among them, in patient with HBeAg negative conversion, the pretreatment quantity of HBV DNA was 10 6 30±1 42 copy/ml, while in those with no HBeAg negative conversion, it was 10 7 23±1 23 copy/ml, the difference was significant. Conclusion: Oxymatrine is effective in treating chronic hepatitis B. The therapeutic effect is better for patients with lower quantity of serum HBV DNA.

关闭