黄芪注射液对急性心肌梗死早期患者左室重塑及心功能的影响

Clinical Study on Effect of Astragalus lnjection on Left Ventricular Remodeling and Left Ventricular Function in Patients with Acute Myocardial Infarction

免费下载全文查看/发表评论下载PDF阅读器

DOI：

中文关键词: 心肌梗死左室重塑心功能黄芪注射液

英文关键词:myocardial infarction left ventricular remodeling cardiac function Astragalus injection

基金项目:

作者	单位
张金国	山东济宁医学院附属医院
高东升	山东济宁医学院附属医院
魏广和	山东济宁医学院附属医院
沈彩云	山东济宁医学院附属医院
王少春	山东济宁医学院附属医院
刘雅洁	山东济宁医学院附属医院
陈廷	山东济宁医学院中心实验室
王学忠	河北省人民医院心脏中心
韩玉平	河北省人民医院心脏中心
诸葛铭宁	河北省人民医院心脏中心

摘要点击次数: 1450

全文下载次数: 1558

中文摘要:

目的 :观察黄芪注射液对急性心肌梗死 (AMI)早期患者左室重塑和心功能的影响。方法 :10 8例AMI患者随机分为黄芪治疗组 (治疗组 ,5 4例 )和常规治疗组 (对照组 ,5 4例 ) ,于治疗 1周及 4周后行超声心动图检查 ,测定左室舒张末容积指数 (LVEDVI)、左室收缩末容积指数 (LVESVI)、左室前部内膜弧长 (ASL)和左室后部内膜弧长 (PSL) ,治疗 4周后同时行核素心血池心室造影 ,判断左室收缩与舒张功能 ;另外 ,治疗前后测定血浆丙二醛 (MDA)、血管内皮细胞数 (CEC)及红细胞膜超氧化物歧化酶 (SOD)水平。结果 :治疗 4周后 ,治疗组LVEDVI、LVESVI和ASL无明显变化 ,而对照组则明显提高 ,两组比较差异有显著性 (P <0 0 5 ) ;治疗组左室射血分数 (LVEF)、左室峰射血率 (PER)及左室峰充盈率 (PFR)较对照组明显提高 ,左室峰充盈率时间 (TPFR)较对照组缩短 ,差异均有显著性 (P <0 0 5 ) ;同时 ,MDA、CEC显著降低 ,而SOD明显升高 ,与治疗前及对照组比较 ,差异均有显著性 (P <0 0 5或P <0 0 1)。结论 :黄芪注射液为预防及逆转AMI左室重塑、改善心脏功能的有效药物之一。

英文摘要:

Objective: To observe the effect of Astragalus injection (AI) on left ventricular remodeling and left ventricular function in patients with acute myocardial infarction (AMI). Methods: AMI patients were randomly divided into the AI group (54 cases) treated with AI and the control group (54 cases) treated with conventional treatment. Left ventricular end diastolic volume index (LVEDVI), left ventricular end systolic volume index (LVESVI), anterior endocardial segmental length (ASL), posterior endocardial segmental length (PSL) were assessed by echocardiogram at the 1st and the 4th week of treatment; and the cardiac systolic and diastolic functions were detected by nuclide gating cardiac blood pool imaging on the 4th week. Besides, the plasmic levels of lipid peroxide (MDA), count of endothelial cell (CEC) and superoxide dismutase (SOD) were determined before and after treatment. Results: At the 4th week, changes of LVEDVI, LVESVI and ASL in the AI group were not obvious, but increased significantly in the control group, the significant difference in comparison between the two groups was shown (P<0 05). As compared with the control group, in the AI group, the left ventricular ejection fraction, left ventricular peak ejecting rate and left ventricular peak filling rate were higher, and the left ventricular time for peak filling rate was shorter, moreover, MDA and CEC were lower and SOD was higher. The difference between groups and between before and after treatment were significant (P<0 01 or P<0 05). Conclusion: AI is one of the effective drugs in reversal of left ventricular remodeling and improving left ventricular function in patients with AMI.

关闭