复方丹参注射液治疗急性脑梗死的疗效及其作用机理探讨

作者	单位
闵连秋	锦州医学院附属第一医院神经内科
党立颖	营口大石桥市陆合医院内科
马维艳	锦州医学院附属第一医院神经内科
袁静	锦州医学院附属第一医院神经内科

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中文摘要:

目的 :从氧自由基和载脂蛋白角度探讨复方丹参注射液治疗急性脑梗死的疗效及机理。方法 :6 8例发病在 1周以内的脑梗死患者 ,随机分为复方丹参研究组 (简称研究组 ,34例 )和血栓通对照组 (简称对照组 ,34例 )进行临床观察。应用比色法测定血清脂质过氧化物 (LPO)和超氧化物歧化酶 (SOD) ,单向免疫法测定载脂蛋白A1(ApoA1)和载脂蛋白B10 0 (ApoB10 0 )。结果 :复方丹参注射液能使患者血清的LPO、ApoB10 0 水平明显降低 ,同时显著升高血清的SOD、ApoA1水平 ,且与对照组治疗后比较 ,差异有显著性 (P <0 0 5或P <0 0 1) ;治疗组的总有效率为 88 2 4 % ,明显高于对照组 (P <0 0 5 )。结论 :复方丹参注射液治疗脑梗死疗效确切 ,抗脂质过氧化损伤和调节载脂蛋白代谢可能是其重要的作用机理。

英文摘要:

Objective: To investigate the curative effect and therapeutical mechanism of composite salvia injection (CSI) in treating ischemic cerebral infarction in the respect of oxygen free radical and apolipoprotein. Methods: Sixty eight cases of ischemic cerebral infarction within the first 72 hrs after onset were divided randomly into the CSI group (treated with CSI) and the control group (treated with Xueshuantong). Serum lipid peroxide (LPO) and superoxide dismutase (SOD) were measured by colorimetry and apolipoprotein A 1 (ApoA 1) and ApoB 100 were measured with unidirectional immune diffusion method. Results: Serum levels of LPO and ApoB 100 were obviously lower, and levels of SOD and ApoA 1 significantly higher in the CSI group than those in the control group (P<0 05 or P<0 01). The total effective rate of CSI in treating cerebral infarction was 88.24%, which was significantly higher than that of the control (P<0 05). Conclusion: CSI shows definite effect in treating cerebral infarction, to reduce the oxygen free radical damage and regulate the apolipoprotein metabolism possibly was the important therapeutical mechanism.

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