米非司酮与氨甲喋呤配合中药治疗异位妊娠的临床观察

作者	单位
苏莹	昆明医学院第二附属医院昆明650101
孙琰	昆明医学院第二附属医院昆明650101
马兰	昆明医学院第二附属医院昆明650101
张素仙	昆明医学院第二附属医院昆明650101

摘要点击次数: 1106

全文下载次数: 1285

中文摘要:

目的 :将两种不同药物治疗异位妊娠的方法进行比较 ,以寻找一种简捷、有效、副作用小的方法。方法 :将 114例异位妊娠患者分为口服米非司酮组 (A组 ) 5 6例 ,肌肉注射氨甲喋呤 (MTX)组 (B组 ) 5 8例 ,两组均加服中药 ,观察比较疗效。结果 :治疗成功率A组为 82 14 % ,B组为 70 6 9% ,差异无显著性 (P>0 0 5 ) ;治疗成功所需时间A组为 (14 5 4± 5 87)天 ,B组为 (9 0 0± 5 0 9)天 ,两组比较差异有显著性意义(P <0 0 1)。两组在恶心、呕吐、腹泻、肝功能异常及白细胞降低等副反应方面差异无显著性 (P >0 0 5 ) ;而月经复潮时间A组为 (43 4 3± 1 77)天 ,B组为 (38 38± 1 13)天 ,两组比较差异有显著性 (P <0 0 5 )。结论 :米非司酮与氨甲喋呤配伍中药治疗异位妊娠两者疗效相似 ,而后者显效更快 ,致月经延迟的副作用较轻

英文摘要:

Objective: To find a simpler, effectiver with less side effect method for treatment of ectopic pregnancy. Methods: One hundred and fourteen patients of ectopic pregnancy were divided into two groups, the 56 patients in Group A were treated with Mifepristone and Chinese herbal medicine (CHM), and 58 patients in Group B were treated with Methotrexate and CHM. The therapeutic effect in both groups was observed and compared. Results: The rate of success in Group A was 82.14% and in Group B 70.69%, comparison between them showed no significance (P>0 05). Time for successful treatment was 14.54±5.87 days in Group A and 9.00±5.09 days in Group B, comparison of them showed significant difference (P<0 01). Insignificance revealed in comparison between the occurrence of side effects for the groups, such as nausea, vomiting, diarrhea, liver dysfunction and lowering of white blood cells, but significance was shown in re menstruation time (43.43± 1.77 days vs 38.38±1.13 days, P<0 05). Conclusion: Treatments of combined CHM with Mifepristone or Methotrexate showed similar therapeutic effect in treating ectopic pregnancy, but the latter showed a quicker initiation and less side effects in delaying the re menstruation time.

关闭