毒素清治疗老年人细菌性肺炎的临床观察

作者	单位
李建生	河南中医学院老年医学研究室
程龙	河南中医学院老年医学研究室
李素云	河南省人民医院老年医学研究所
马利军	河南省人民医院老年医学研究所
孔桂莲	河南中医学院老年医学研究室
王凯	河南省人民医院老年医学研究所
陈献亮	河南省人民医院老年医学研究所
吴记珍	河南省人民医院老年医学研究所

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中文摘要:

目的:评价毒素清治疗老年人细菌性肺炎的临床疗效及其可能的机理。方法:按照随机对照原则,治疗组在西医常规治疗的基础上,加用毒素清口服液治疗,对照组单用西医常规治疗,并检测两组患者治疗前后外周血白细胞介素2（IL-2）和肿瘤坏死因子-α（TNF-α）的变化。结果:总有效率治疗组为93.9％,对照组为83.9％,两组比较差异有显著性（P<0.05）。两组治疗后主症积分、次症积分、总积分均明显降低,且治疗组积分降低更明显。老年患者外周血IL-2水平显著低于健康老年人组,TNF-α水平显著高于健康老年人组;治疗后治疗组TNF-α水平降低,而IL-2水平上升并接近健康老年人水平。对照组上述两项治疗前后均无明显变化。结论:毒素清治疗老年人细菌性肺炎具有明显疗效,其作用机理可能与通过提高IL-2水平,改善机体免疫功能,降低过度分泌的TNF-α等炎性细胞因子水平有关。

英文摘要:

Objective: To evaluate the clinical effect of Dusuqing (DSQ) in treating senile bacterial pneumonia and to explore its possible mechanism. Methods: Patients were randomly divided into two groups, the treated group treated with conventional western therapy (CWT) and the combined-treated group treated with CWT plus DSQ respectively. The changes of serum cytokines, interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α), before and after treatment were observed. Results: In the 33 patients of the combined treated group, the total effective rate being 93.9% . While in the 31 patients of treated group, the total effective rate being 83. 9% . The difference of the total effective rate between the two groups was significant (P<0.05) . The scores of principal symptoms, secondary symptoms and total scores were all obviously lowered in both groups, particularly in the combined treated group. The peripheral blood IL-2 level was lower and TNF-a higher in senile patients than those in healthy aged subjects respectively. All the two parameters approached normal level in the combined treated group but with insignificant change in the CWT treated group. Conclusion: DSQ showed obvious effect in treating senile bacterial pneumonia. The mechanism might be related with the lowering of inflammatory cytokines such as oversecreted TNF-α, as well as the improvement of immune function (elevation of IL-2) of organism.

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