黄芪在恶性肿瘤化疗中的增效减毒作用的临床研究

目的:观察黄芪在恶性肿瘤化疗中的增效减毒作用。方法:将120例确诊的恶性肿瘤患者随机分为黄芪组与对照组,黄芪组于化疗同时予黄芪注射液20ml加生理盐水250ml静脉滴注,每天1次,21天为1个疗程,连用4个疗程;对照组单纯用化疗。结果:与对照组比较,黄芪组的病变进展率、外周血WBC、PLT降低程度小（P<0.05）;CD8下降明显（P<0.05）,CD4/CD8比值上升明显（P<0.01）,血清IgG、IgM含量明显增高（P<0.05）;两组血清IgA含量无明显变化;Karnofsky评分黄芪组明显高于对照组（P<0.01）。结论:黄芪辅助化疗可抑制肿瘤进展,降低毒副反应,提高机体的免疫功能和改善生活质量。

英文摘要:

Objective: To observe the effect of Astragalus membranaceus efficacy enhancing and toxicity reducing on chemotherapy in patients of malignant tumor. Methods: One hundred and twenty tumor patients were randomly divided into the treated group and the control group. Both groups were treated with chemotherapy, but to the treated group, Astragalus injection was given additionally by intravenous dripping, 20 ml in 250 ml of normal saline once per day for 21 days as one course and 4 courses were given successively. Results: Compared with the control group, the treated group showed a lower progressive incidence, lesser decrease of peripheral WBC and platelet count (P<0.05), accompanied with CD8 significantly lowered (P<0.05), CD4/CD8 ratio significantly increased (P<0.01), IgG arid IgM levels raised (P<0.05) and Karnofsky scores elevated more than those in the control group. IgA level was unchanged in both groups. Conclusion: Astragalus injection supplemented with chemotherapy could inhibit the development of tumor, decrease the toxic-adverse effect of chemotherapy, elevate the immune function of organism and improve the quality of life in patients.

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