降压脉净液对高脂饮食自发性高血压大鼠的影响

作者	单位
黄力	中日友好医院北京100029
史载祥	中日友好医院北京100029
张久亮	中日友好医院北京100029
毛建生	中日友好医院北京100029
罗杰	中日友好医院北京100029

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中文摘要:

目的:观察并验证降压脉净液对高脂饮食自发性高血压大鼠（SHR）的降压、降脂作用及肾脏的病理变化。方法:将42只SHR分为5组:A组用普食,B组用高脂饮食,C组用高脂饮食加降压脉净液治疗,D组用高脂饮食加西药治疗,E组用高脂饮食加牛黄降压丸治疗,F组为正常大鼠（WKY）用普食。观察治疗后14周血压、生化指标及肾脏病理学改变。结果:（1）血压变化:A、B组血压升高最明显;C组用药后第5周开始血压处于相对平稳阶段,比A、B、D、E组为低（P<0.01）。（2）一氧化氮（NO）:C、D组较B、E组明显升高（P<0.05或P<0.0 1）。（3）胆固醇（CHO）:C、D组均较B组明显降低（P<0.01）,而C组降低更明显（P<0.01和P<0.05）。（4）肾脏病理改变上组病变最为严重（P<0.01）;C组病变改善最为明显（P<0.01）。结论:（1）高血压合并高脂血症其病变程度比单纯高血压严重。（2）降压脉净液对SHR血压具有控制其发展的作用,其降压机理可能与提高血中NO有关。（3）降压脉净液具有降脂作用。（4）降压脉净液通过降压、降脂,从而减轻了肾脏病理改变,具有保护肾脏的作用。

英文摘要:

Objective: To observe and identify the effect of Jiangya Maijing Liquid (JYMJL) on spontaneous hypertension rats (SHR) fed with high lipid diet in antagonizing hypertension and hyperlipidemia and improving pathological changes of kidney. Methods: Forty-two SHR were divided into 5 groups, except Group A, the Groups B - E were fed with high lipid diet, and Group C, D and E was treated with JYMJL, western drug and Niuhuang Jiangya pill respectively. Besides, Group F was set up for control with normal rats fed by normal diet. The changes of blood pressure (BP), biological indices and renal pathology were observed in the 14 weeks’ period of observation. Results: (1)BP raised significantly in Group A and B, it became stable in Group C from the 5th week on and was lower than the BP in other groups (P<0.01). BP in Group F was not changed; (2) The highest level of nitric oxide (NO) was shown in Group F, and that in Group B and E was lower than that in Group C and D; (3) Level of cholesterol was lower in Group A and F than that in Group C, D and E (F< 0.01), and that in Group C was lower than that in Group B and E (P<0.01 and F<0.05 respectively); (4) Pathologic examination on kidney showed that no change was found in Group F, the most severe change was shown in Group B among Group B-E, and the improvement after treatment in Group C was better than that in group B (P<0.01). Conclusion: (1) Condition of disease in rats with hypertension complicated with hyperlipidemia was more severe than that with simple hypertension; (2) JYMJL could restrain the developing of hypertension in SHR, the mechanism may be related with the raising of NO; (3) JYMJL has effect of lowering blood lipid; (4) JYMJL has kidney protective effect, it could alleviate the pathological changes in kidney by way of lowering BP and blood lipid.

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