甲氨喋呤和柳氮磺胺吡啶联合中药治疗类风湿性关节炎的临床观察

作者	单位
卢思俭	山东省胜利石油管理局胜利医院山东257055
邵璟	山东省胜利石油管理局胜利医院山东257055
李相如	山东省胜利石油管理局胜利医院山东257055
杨晓红	山东省胜利石油管理局胜利医院山东257055

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中文摘要:

目的 :观察风湿Ⅰ号辅助治疗类风湿性关节炎 (RA)活动期的初步疗效。方法 :筛选活动期RA患者 6 0例 ,随机分为治疗组 4 0例 ,口服风湿Ⅰ号、甲氨喋呤 (MTX)和柳氮磺胺吡啶 (SSZ)。对照组 2 0例 ,口服MTX、SSZ用量、用法同治疗组。结果 :治疗组总有效率 (97 5 % )、临床控显率 (95 0 % )、毒副反应发生率 (10 0 % )分别与对照组总有效率 (6 0 0 % )、临床控显率 (2 0 0 % )、毒副反应发生率 (45 0 % )比较差异均有显著性 (χ2 =11 91、32 2 3、7 6 7,P <0 0 1)。治疗组在减轻关节肿胀、疼痛 ,改善关节功能 ,降低免疫学指标 ,改善影像学的表现方面均优于对照组 (P <0 0 5或P <0 0 1)。结论 :风湿Ⅰ号不仅具有抗炎镇痛、调节免疫反应的作用 ,而且可延缓骨破坏的发生 ,减少MTX、SSZ毒副反应。

英文摘要:

Objective: To observe the effect of Fengshi No.1 (FS1) in treating patients with active stage of rheumatoid arthritis (RA). Methods: Patients with RA were randomly divided into two groups, the 40 patients in the treated group were treated with combined therapy of methotrexate (MTX), sulfasalazine (SSZ) and FS1, and the 20 in the control groups were treated with MTX and SSZ alone. Results: In the treated group, the total effective rate was 97.5%, the clinical controlled and markedly effective rate 95.0% and the occurrence rate of side toxic reaction 10.0%, as compared with those in the control group, 60.0%, 20.0% and 45.0% respectively, the difference was significant (χ 2=11.91, 32.23 and 7.67 respectively, all P<0 01). The effect in the treated group was superior to that in the control group in abating joint swelling and pain, improving function of joint, reducing immune indices and ameliorating iconographic features (P<0 01 or P<0 05). Conclusion: FS1 not only has the effects of anti inflammation, analgesis, regulating immune reaction, but also could retard the occurring of bone destruction, reduce the toxic side effects of MTX and SSZ.

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