咳速宁颗粒剂治疗慢性支气管炎急性发作的临床观察

作者	单位
毛兵	四川大学华西医院成都610041
张瑞明	四川大学华西医院成都610041
李廷谦	四川大学华西医院成都610041
陈光远	四川大学华西医院成都610041
常静	四川大学华西医院成都610041
夏庆	四川大学华西医院成都610041

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中文摘要:

目的 :验证咳速宁颗粒剂对慢性支气管炎急性发作期 (痰热证 )的疗效 ,并对其安全性作出客观评价。方法 :采用双盲双模拟随机对照试验 ,选择慢性支气管炎急性发作 (痰热证 )患者 12 0例 ,随机分为咳速宁颗粒剂组 (治疗组 ) 6 0例 ,金贝痰咳清颗粒剂组 (对照组 ) 6 0例。治疗组给予咳速宁颗粒剂 ,每日 3次 ,每次 8g ,对照组给予金贝痰咳清颗粒剂 ,每日 3次 ,每次 7g ,疗程均为 6天。结果 :临床总体疗效 :治疗组显效率 5 8 33% ,有效率 93 33% ;对照组显效率 5 1 6 7% ,有效率 91 6 7%。两组临床总体疗效比较差异无显著性 (P >0 0 5 )。中医证候疗效 ;治疗组显效率 6 8 33% ,有效率 93 33% ;对照组显效率 6 6 6 7% ,有效率90 0 0 %。两组中医证候疗效比较差异亦无显著性 (P >0 0 5 )。两组平均起效时间比较治疗组显著优于对照组 (P <0 0 5 )。临床观察中 ,未发现明显不良反应。结论 :咳速宁颗粒剂临床疗效确切 ,未发现明显毒副反应。

英文摘要:

Objective: To prove the effect of Kesuning Granule (KSNG) in treating chronic bronchitis in exacerbation (Phlegm Heat syndrome) and objectively evaluate its safety. Methods: The double blinded, double dummy and randomized controlled method was adopted to observe 120 patients, who were divided into the treated group (n=60, treated with KSNG 8g, three times a day) and the control group (n=60, treated with Jinbei Tankeqing Granule (JBTKQ) 7g, three times a day). The therapeutic course for both groups was 6 days. Results: In the treated group, the markedly effective rate was 58.33% and effective rate was 93.33%, while in the control group, they were 51.67% and 91.67% respectively, no significant difference was found between the two groups. For therapeutic effects on TCM syndromes, the markedly effective rate and effective rate in the treated group was 68.33% and 93.33% respectively and in the control group, 66.67% and 90.00% respectively, also showed insignificant difference. The effect initiative time was earlier in the treated group than that in the control group significantly (P<0 05). No adverse effect was found in the observation. Conclusion: KSNG shows a definite clinical effect with no obvious toxic adverse effects.

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