| 陈芝芸,严茂祥,项柏康.肠易激综合征中医证型与胃肠激素关系的探讨[J].中国中西医结合杂志,2002,(9):664-666 |
| 肠易激综合征中医证型与胃肠激素关系的探讨 |
| Study on Relationship between TCM Syndrome Type of Irritable Bowel Syndrome and Gut Hormones |
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| DOI： |
| 中文关键词: 肠易激综合征 中医分型 胃肠激素 |
| 英文关键词:irritable bowel syndrome TCM syndrome typing gut hormones |
| 基金项目:浙江省自然科学基金资助项目 (No .39641 7) |
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| 中文摘要: |
| 目的 :探讨肠易激综合征 (IBS)不同中医证型血浆胃肠激素的变化及其临床意义。方法 :选择符合罗马Ⅱ诊断标准的IBS患者 94例 ,按中医分型标准分为肝郁脾虚组 4 2例 ,脾胃虚弱组 30例 ,脾胃阴虚组 2 2例 ,采用放免法检测患者血浆神经肽Y(NPY)、P物质 (SP)、血管活性肠肽 (VIP)、胰高糖素 (Glu)的含量。结果 :肝郁脾虚组患者血浆VIP、Glu含量较健康对照组增高 ,NPY、SP含量与健康对照组比较差异无显著性 ,但NPY含量明显高于脾胃阴虚组 ,SP含量则显著低于脾胃阴虚组 ;脾胃虚弱组患者血浆VIP、Glu含量高于健康对照组 ,SP低于健康对照组和脾胃阴虚组 ,NPY与健康对照组比较差异无显著性 ;脾胃阴虚组患者血浆SP、Glu较健康对照组增高 ,NPY则低于健康对照组 ,而VIP与健康对照组比较差异无显著性。结论 :不同中医证型IBS患者血浆胃肠激素有一定的变化。其中NPY和SP的变化有证型的特异性 ,而VIP、Glu的变化无明显的证型特异性。 |
| 英文摘要: |
| Objective: To explore the changes of gut hormones in various TCM Syndrome types of irritable bowel syndrome (IBS) patients and its significance. Methods: Ninety four patients with IBS, whose diagnosis conformed to the Rome Ⅱ diagnostic standard, were divided into three groups according to TCM Syndrome typing, i.e. the 42 patients in the Liver Stagnancy with Spleen Deficiency (LSSD) group, 30 in the Spleen Stomach Deficiency (SSD) group and 22 in the Spleen Stomach Yin Deficiency (SSYD) group. Plasma contents of neuro peptide Y (NPY), substance P(SP), vascular active intestinal peptide (VIP) and pancreatic glucagon (Glu) of patients were determined by radioimmunoassay (RIA), and compared with those of the healthy persons. Results: Blood contents of VIP and Glu in LSSD patients were higher than thosein the healthy control, NPY and SP were similar to thosein the healthy control, while NPY was higher and SP lower than that of SSYD patients respectively. In the SSD group, VIP and Glu were higher than those of the healthy control, SP was lower than that in the control and in SSYD group, and NPY was different from the control insignificantly. In the SSYD group, SP and Glu was higher and NPY lower than those of control, while VIP was not significantly different from the control. Conclusion: Some changes of gut hormones were presented in patients with IBS of various TCM Syndrome types, among them, the changes of NPY and SP showed Syndrome specificity, but changes of VIP and Glu did not show. |
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