中药加味桂枝人参汤治疗化疗毒副反应临床观察

目的 :观察加味桂枝人参汤对化疗引起的毒副反应的影响。方法 :对未接受 5 HT3受体拮抗剂及集落刺激因子治疗的晚期肿瘤患者 6 0例 ,分为治疗组 (化疗加中药治疗 )及对照组 (单用化疗 ) ,观察治疗前后外周血白细胞及血小板、T细胞及亚群、胃肠道反应等指标变化。结果 :白细胞及血小板 :治疗组治疗后与治疗前比较 ,差异无显著性 (P >0 0 5 ) ,但高于对照组治疗后 (P <0 0 1) ;对照组治疗后较治疗前减少 (P <0 0 1)。T细胞及亚群变化与白细胞及血小板情况类似。胃肠道反应情况 :治疗后治疗组有 17例只有恶心的感觉 ,13例有轻度呕吐 ;对照组恶心 6例 ,轻度呕吐 7例 ,中度呕吐 14例 ,难治性呕吐 3例。结论 :加味桂枝人参汤对机体部分免疫功能具有保护和促进作用 ,并能防治化疗所致的骨髓抑制 ,减轻胃肠道反应。

英文摘要:

Objective: To observe the effects of Jiawei Guizhi Renshen decoction (JGRD) in treating toxic side effects of chemotherapy. Methods: Sixty patients of advanced tumor, who had not been treated by 5 HT 3 receptor antagonists and colony stimulating factors, were divided into the treated group (treated with chemotherapy plus JGRD) and the control group (treated with chemotherapy alone). The changes of peripheral white blood cell, platelet, T lymphocyte and its subsets, as well as the gastrointestinal reactions were observed before and after treatment. Results: After treatment, in the treated group, WBC, platelet, T lymphocyte and its subsets, were not changed significantly as compared with before treatment, but comparison of these parameters between the two groups after treatment showed significantly difference (P<0 01), i.e. those parameters decreased significantly in the control group after treatment (P<0 01). Mild nausea occurred in 17 patients and vomiting in 13 in the treated group, but in the control group, nausea occurred in 6 patients, mild vomiting in 7, moderate vomiting in 14 and severe vomiting in 3. Conclusion: JGRD has protection and promotion on partial immune function of organism, it could prevent and treat bone marrow inhibition and relieve the gastrointestinal reaction induced by chemotherapy.

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