益气养阴活血法对早期糖尿病肾病患者一氧化氮的影响

Effect of TCM Treatment with Principle of Supplementing-Qi Nourishing-Yin and Activating Blood Circulation on Nitric Oxide in Patients with Early-stage Diabetic Nephropathy

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中文关键词: 益气养阴活血早期糖尿病肾病一氧化氮

英文关键词:supplementing-Qi nourishing-Yin and activating blood circulation early stage diabetic nephropathy nitric oxide

基金项目:

作者	单位
范冠杰	广西中医学院第一附属医院南宁530023
唐咸玉	广西中医学院第一附属医院南宁530023
李双蕾	广西中医学院第一附属医院南宁530023
唐爱华	广西中医学院第一附属医院南宁530023
罗广波	广西中医学院第一附属医院南宁530023
刘春红	广西中医学院第一附属医院南宁530023

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中文摘要:

目的:观察以益气养阴活血法为主治疗早期糖尿病肾病(DN)患者的疗效及对一氧化氮(NO)的影响。方法:将入选的65例患者随机分为对照组(31例)和治疗组(34例),对照组予糖尿病教育、常规降血糖及对症处理,治疗组加用以益气养阴活血为主的中药治疗。结果:早期糖尿病肾病患者NO明显升高,治疗8周后,两组均能较好地降低症状积分、空腹血糖(FBG)及24h尿微量白蛋白排泄量(UAE)。治疗组在改善患者症状、降低UAE及N0水平方面,疗效明显优于对照组(P<0.05或P<0.01),对照组对NO改善不明显。结论:提示DN早期高N0生成与肾小球高滤过有关,益气养阴活血法为主可能通过降低肾脏NO水平,改善肾小球的高滤过。

英文摘要:

To observe the clinical effect of the therapeutic principle of supplementing-Qi nourishing-Yin and activating blood circulation (SNA) on nitric oxide (NO) level in patients with early stage diabetic nephropa-thy (DN). Methods: Patients with DN were randomly divided into two groups, 31 in the control group and 34 in the treated group. Training on awareness of diabetes, conventional hypoglycemic and symptomatic treatment were given to the patients in the control group, to the patients in the treated group, mainly the treatment of SNA was given additionally. Results: After 8 weeks treatment, the clinical symptom scores of DN lowered, the urinary albumin excretion/24 hrs and NO level decreased significantly in the treated group, as compared with the control group, the difference was significant (P<0.05 or P<0.01), while the decrease of NO level in the control group after treatment was insignificant. Conclusion: The high production of NO in early stage DN is related with the glomerular hyperfiltration, SNA treatment could improve the glomerular hyperfiltration through decreasing the NO level in kidney.

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