黄芪注射液对充血性心力衰竭患者免疫功能的影响

作者	单位
刘志高	华中科技大学同济医学院附属梨园医院心内科
熊正明	华中科技大学同济医学院附属梨园医院心内科
余细勇	广东省心血管病研究所临床药理室

摘要点击次数: 1888

全文下载次数: 2006

中文摘要:

目的 :研究黄芪注射液对充血性心力衰竭 (CHF)患者体液免疫 (IgG、IgA、IgM )、细胞免疫 (T细胞亚群 )及可溶性白细胞介素 2受体 (sIL 2R)的影响。方法 :将 6 2例属NYHA心功能分级为 2～ 4级的住院患者随机分为两组。在西医常规治疗的同时 ,治疗组加用黄芪注射液 30ml(相当于生药 6 0 g)加入 5 %葡萄糖注射液 5 0 0ml中静脉滴注。每天 1次 ;对照组用硝酸甘油 10mg加入 5 %葡萄糖注射液 5 0 0ml中静脉滴注 ,每天 1次。疗程均为 2 0天。两组治疗前后均采血测定IgG、IgA、IgM、T细胞亚群和sIL 2R ,同时进行临床疗效评价。结果 :治疗组临床心功能改善显效率及总有效率分别为 2 5 8%、74 2 % ,明显优于对照组 (P<0 0 5 ,P <0 0 1)。两组治疗后的左室射血分数 (LVEF)和收缩末期容积 (ESV)较治疗前均有明显改善 (P<0 0 5 ,P <0 0 1) ,且治疗组优于对照组 (P <0 0 5 )。治疗后治疗组的CD4 和CD4 /CD8比值上升 (P <0 0 5 ) ,sIL 2R明显下降 (P <0 0 5 ) ,IgG、IgA明显下降 (P <0 0 5 ) ;对照组各项指标无明显变化 (P >0 0 5 )。结论 :黄芪注射液能够改善患者的免疫功能 ,可作为治疗CHF的重要辅助药物。

英文摘要:

Objective: To study the effect of Astragalus Injection (AI) on the humoral immunity (IgG, IgA and IgM), cellular immunity (T lymphocyte subsets) and soluble interleukin 2 receptor (sIL 2R) in patients with congestive heart failure (CHF). Methods: Sixty two in patients with CHF, whose heart function belonged to NYHA grade Ⅱ-Ⅳ, were randomly divided into two groups. The treated group was treated with AI 30 ml (equivalent to 60 g crude drug), and the control group was treated by nitroglycerine injection 10 mg, the drugs were administered respectively by adding in 5% glucose solution 500 ml for intravenous dripping, once a day, 20 days as one therapeutic course. Venous blood from cubital vein was collected before and after treatment to detect the IgG, IgA, IgM, T lymphocyte subsets and sIL 2R, and the clinical effect of treatment was evaluated. Results: The clinical heart function markedly improved rate and total effective rate in the treated group was 25.8% and 74.2% respectively, significantly better than those in the control group respectively (P<0 05 or P<0 01), the left ventricular ejecting fraction (LVEF) and end syctolic volume (ESV) were improved in both groups (P<0 05, P<0 01), and the improvement in the treated group was superior to that in the control group (P<0 05). In the treated group after treatment, the CD 4 level and CD 4/CD 8 ratio increased (P<0 05), levels of sIL 2R, IgG and IgA lowered (P<0 05) significantly, while those in the control group were not changed significantly (P>0 05). Conclusion: AI could improve the immune function of CHF patients, and can be taken as an important auxiliary treatment for CHF.

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