| 赵健雄,连平,李玉田,沈世林.扶正抑瘤颗粒对乳腺癌核转录因子-kB及细胞周期的影响[J].中国中西医结合杂志,2003,(6):421-422 |
| 扶正抑瘤颗粒对乳腺癌核转录因子-kB及细胞周期的影响 |
| Effect of Fuzheng Yiliu Granule on Nuclear Transcriptional Factor-kB and Cell Cycle in Patients with Breast Carcinoma |
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| DOI： |
| 中文关键词: 扶正抑瘤颗粒 乳腺癌 核转录因子-κB 细胞周期 |
| 英文关键词:Fuzheng Yiliu granule breast carcinoma nuclear transcriptional factor-kB cell cycle |
| 基金项目:教育部重点项目(No.01128) |
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| 中文摘要: |
| 目的:研究扶正抑瘤颗粒（FYK）对乳腺癌肿瘤组织核转录因子-κB（NF-κB）和细胞周期的影响及其临床意义。方法:55例乳腺癌患者,随机分为治疗组和对照组,两组均用常规化疗,治疗组同时口服FYK,1个月后取肿瘤组织用流式细胞仪检测NF-κB的表达情况及肿瘤细胞周期各时相的比例。结果:治疗组与对照组比较,NF-κB的表达明显提高（P<0.01）;G0/1期细胞比例明显升高（P<0.01）,S期细胞比例及细胞增殖指数（PI）明显下降（P<0.01）。结论:FYK可提高乳腺癌组织NF-κB表达水平;能升高G0/1期细胞比例,降低S期细胞比例及PI值,对乳腺癌患者的预后起积极作用。 |
| 英文摘要: |
| Objective: To explore the effect and clinical significance of Fuzheng Yiliu Granule (FYG) on nuclear tran-scriptional factor-kB (NF-kB) and cell cycle in breast tumor. Methods:Fifty-five patients of breast carcinoma were randomly divided into the treated group and the control group, both were treated with conventional chemotherapy, but to the treated group, FYG was given additionally by oral taking. Operation was performed one month later to take out the tumor tissue for detecting NF-kB expression and ration of cells in different phases of cell cycle. Results: Compared with the control group, NF-kB expression was significantly increased in the treated group, accompanied with increased G0/1 phase cell proportion and decreased S phase cell proportion as well as significantly reduced cell proliferation index (all P<0.01). Conclusion: FYG could enhance the expression of NF-icB in breast tumor tissue, raise the proportion of G0/1 phase cells, decrease proportion S phase cells and reduce the cell proliferation index, showing an active action on the patients prognosis. |
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