中药胃肠安防治进展期胃癌术后转移的临床研究

作者	单位
杨金坤	海中医药大学附属龙华医院肿瘤一科上海200032
郑坚	海中医药大学附属龙华医院肿瘤一科上海200032
沈克平	海中医药大学附属龙华医院肿瘤一科上海200032
韩颖盈	海中医药大学附属龙华医院肿瘤一科上海200032
顾缨	海中医药大学附属龙华医院肿瘤一科上海200032
朱莹杰	海中医药大学附属龙华医院肿瘤一科上海200032
周浩	海中医药大学附属龙华医院肿瘤一科上海200032
赵爱光	海中医药大学附属龙华医院肿瘤一科上海200032
赵海磊	海中医药大学附属龙华医院肿瘤一科上海200032
杨金祖	海中医药大学附属龙华医院肿瘤一科上海200032

摘要点击次数: 1355

全文下载次数: 2119

中文摘要:

目的 :观察中药胃肠安对进展期胃癌术后转移的影响。方法 :采用前瞻性随机分组对照 ,将 14 8例进展期胃癌根治术后患者分为胃肠安组、化疗组和胃肠安加化疗组 (简称中西医组 )。观察 3组患者的生存率、转移率、生存质量和转移复发后带瘤生存时间。结果 :胃肠安组的术后 1、2、3年生存期分别为93 2 3%、79 34%、71 78% ,中西医组分别为 89 5 1%、6 9 77%、5 5 76 % ,明显高于化疗组的 83 86 %、5 9 33%、4 9 4 3% (P <0 0 5 ) ;胃肠安组与中西医组比较差异无显著性。 1、2、3年转移率胃肠安组分别为15 2 5 %、2 8 81%、33 90 % ,中西医组分别为 15 5 2 %、4 1 38%、4 6 5 5 % ,但只有术后 1年转移率胃肠安组及中西医组与化疗组比较 ,差异有显著性 (P <0 0 5 ) ;2、3年转移率差异无显著性 ,但均明显低于化疗组 (分别为 35 4 8% ,4 5 16 % ,5 1 6 1% )。胃肠安组的生存质量和复发转移后的生存时间明显好于化疗组 (P <0 0 5 )。结论 :中药胃肠安对胃癌术后患者的复发转移有防治作用。

英文摘要:

Objective:To observe the effect of Weichang′an (WCA, a Chinese preparation) in preventing post-operative metastasis of progressive stage of gastric cancer. Methods:A prospective randomized, controlled study was conducted by dividing the 148 patients of progressive staged gastric cancer after radical operation into the WCA group, the chemotherapy (CT) group and the WCA+CT group, to observe the survival rate, metastasis rate, quality of life (QOF) and tumor-bearing survival time after relapse (TST) in patients. Results:The 1-, 2- and 3-year survival rate after operation in the WCA+CT group was 89.51%, 69.77% and 55.76% respectively, which was significantly higher than that in the CT group (83.86%, 59.33% and 49.43%) respectively (P<0 05), but showed insignificant difference as compared with that in the WCA group (93.23%, 79.34% and 71.78%). Only 1-year metastasis in the WCA group was 15.25%, and in the WCA+CT group was 15.52%, the two were significantly lower than that in the CT group (35.48%, P<0 05). But the comparison of 2-year metastasis rate among the 3 groups (28.81%, 41.38% and 45.16%) and 3-year metastasis rate among them (33.90%, 46.55% and 51.61%) were insignificantly different. The QOF and TST were markedly better in the WCA group than those in the CT group. Conclusion:WCA has preventive effect on relapse and metastasis in post-operational gastric cancer patients.

关闭