丹地片对绝经后女性血脂及性激素的影响

作者	单位
梁瑞宁	江西中医学院附属医院
陈明人	江西中医学院附属医院
徐晓	江西中医学院附属医院
潘兆兰	江西中医学院附属医院
胡小荣	江西中医学院附属医院
周士源	江西中医学院附属医院
张红花	广东省东莞市樟木头医院
姜玉婵	江西中医学院

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中文摘要:

目的 :探讨补肾活血剂———丹地片对绝经后女性血脂及性激素的影响。方法 :将 73例绝经后女性随机分为两组 ,丹地组 (4 6例 )采用丹地片 (由熟地 2 4 g　山茱萸 9g　茯苓 9g　泽泻 9g　牡丹皮 9g　淮山药 12 g　丹参 15g等组成 )治疗 ,每次 4片 ,每日 2次 ,对照组 (2 7例 )口服维尼安 (乙炔雌二醇戊醚 ,每片含2 5mg) ,每月 5mg ,连用 3个月 ,分别于治疗前后测定血脂 (TC、TG、HDL C、LDL C)、载脂蛋白 (apoA、apoB)及性激素 (FSH、E2 )水平。结果 :两组治疗后TC/HDL C、FSH下降 ,HDL C、E2 上升 ,与治疗前比较 ,差异均有显著性 (P <0 0 5或P <0 0 1) ;且丹地组TG下降 ,apoA上升 ,与治疗前比较 ,差异亦有显著性 (P <0 0 5 )。结论 :丹地片具有提高雌激素水平 ,改善血脂代谢的作用 ,对绝经后妇女冠心病的发生有预防作用。

英文摘要:

Objective:To explore the effect of Dandi Tablet (DDT), a TCM preparation for tonifying Shen and activating blood circulation, on blood lipids and sex hormones in women of postmenopausal stage. Methods:Seventy-three women were randomly divided into two groups. The 46 subjects in the DDT group were treated with DDT (consisted of prepared Rehmannia Root 24 g, Dogwood Fruit 9 g, Poria 9 g, Water-plantain 9 g, Tuber Peony bark 9 g, Chinese Yam 12 g and Red Sage 15 g, etc.) twice a day, 4 tablets each time. The 27 subjects in the control group were treated with nylestriol (each tablet contains 2.5 mg of 17α-ethynylestriol-3-cyclopentyl ether) 5 mg every month, for 3 successive months. Levels of blood lipids, including total cholesterol (TC), triglyceride (TG), high and low density lipoprotein cholesterol (HDL-C, LDL-C), apoprotein A and B (apoA, apoB) and sex hormones, including follicular stimulating hormone (FSH) and estradiol (E 2) were determined before and after treatment. Results:Compared with pre-treatment, after treatment, levels of TC/HDL-C and FSH significantly lowered, HDL-C and E 2 increased in both groups (P<0 05 or P<0 01), levels of TG lowered and apoA increased significantly in the DDT group (P<0 05). Conclusion:DDT has the effect of elevating levels of estrogen and improving blood lipid metabolism, therefore shows a coronary heart disease preventive effect in women of postmenopausal stage.

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