中药防治鼻咽癌放疗致视后路损伤的研究

Study on Prevention and Treatment of Radiotherapy Caused Post-visual Pathway Injury in Nasopharyngeal Carcinoma Patients by Traditional Chinese Medicine

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DOI：

中文关键词: 中药鼻咽癌视后路放射损伤

英文关键词:Chinese medicine nasopharyngeal carcinoma post-visual pathway radiation injury

基金项目:广东省中医药管理局课题基金 (No.99549);中山大学肿瘤防治中心 2 0 0 0年科研基金资助

作者	单位
徐伯平	中山大学肿瘤医院中医科
龙时先	中山大学眼科中心视觉生理研究室
胡伟汉	中山大学肿瘤医院放疗科
余敏忠	中山大学眼科中心视觉生理研究室
方盛华	中山大学中山医院临床医学系
黄时洲	中山大学眼科中心视觉生理研究室
夏云飞	中山大学肿瘤医院放疗科
古模发	中山大学肿瘤医院放疗科
高剑铭	中山大学肿瘤医院放疗科
吴少雄	中山大学肿瘤医院放疗科

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中文摘要:

目的 :观察中药防治鼻咽癌放疗致视后路损伤的作用。方法 :将 35例鼻咽癌患者随机分成单纯放疗组 (简称单放组 ,17例 )和中药加放疗组 (简称中放组 ,18例 ) ,中放组在放疗期间加用中药方剂“睛明方”。两组在放疗前和结束时均采用多焦视诱发电位检查仪对诱发电位的潜伏期和振幅进行测定。结果 :上、下视野诱发电位的潜伏期 ,单放组放疗后与放疗前比较均延长 ,差异有显著性 (P <0 0 5 ) ;中放组放疗后与放疗前比较差异无显著性 (P >0 0 5 )。上视野诱发电位的振幅 ,单放组放疗后较放疗前明显降低 (P <0 0 5 ) ;中放组治疗前后比较差异无显著性 (P >0 0 5 )。下视野诱发电位振幅 ,单放组放疗前后差异无显著性 (P >0 0 5 ) ;中放组放疗后较放疗前升高 (P <0 0 5 )。结论 :中药“睛明方”有防治放射线对视后路损伤的作用。

英文摘要:

Objective: To study the effect of TCM in preventing and treating post-visual pathway injury caused by radiotherapy (RT) for nasopharyngeal carcinoma (NPC). Methods: Thirty-five patients of NPC were randomly divided into the RT group (n=17) and the RT+TCM group (n=18), they were all received RT, but the latter was treated additionally with Jingming recipe, a Chinese recipe. The latent period and amplitude of evoked potential (EP) were measured before and after ending of RT, using multi-focusing visual evoked potential inspector. Results: The latent time of EP, both upper and lower visual field, was prolonged significantly after RT in the RT group (P<0 05), but not in the RT+TCM group (P>0 05); the amplitude of EP of upper visual field lowered significantly (P<0 05) in the RT group but insignificantly in the RT+TCM group (P>0 05); as for the EP amplitude of lower visual field, it was unaltered in RT group after RT (P>0 05), but increased in the RT+TCM group (P<0 05). Conclusion: The Chinese medicine Jingming recipe was effective in preventing and treating RT induced post-visual pathway injury.

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