再障饮配合西药治疗再生障碍性贫血临床观察

目的 :研究中药复方再障饮对慢性再生障碍性贫血患者免疫功能的影响。方法 :测定再障饮治疗前后患者T淋巴细胞亚群、血清肿瘤坏死因子 (TNF α)、白细胞介素 2 (IL 2 )的水平 ,并用常规治疗组和正常组做对照分析其变化规律。结果 :再障饮治疗前CD4 明显降低、CD8升高、CD4 /CD8降低 ;TNF α、IL 2均升高 ,与正常组比较差异有显著性 (P <0 0 5 )。再障饮治疗后CD4 升高、CD8降低、CD4 /CD8升高 ;TNF α、IL 2均降低 ,与治疗前及对照组比较差异均有显著性 (P <0 0 5 )。结论 :再障饮可能通过改善T淋巴细胞比例及减少TNF α、IL 2等造血负调控因子的释放 ,解除对造血功能的抑制而促进造血功能的恢复。

英文摘要:

Objective: To study the effect of Composite Zaizhang decoction (ZZD) on immune function of chronic aplastic anemia (CAA) patients. Methods: To determine the levels of T-lymphocyte subset, serum tumor necrosis factor (TNF-α) and interleukin-2 (IL-2) in CAA patients before and after treatment, and to analyse the regulation of their changes comparatively with the group treated with conventional treatment and a normal control group. Results: Before treatment, CD 4 was lower, CD 8 higher, CD 4/CD 8 ratio also lower, TNF-α and IL-2 were higher in the ZZD treated group than those in the normal control group, with significant difference (P<0.05), but after ZZD treatment, these indexes were all inversely changed, as compared with those before treatment and with those in the control group, the difference was significant (P<0.05). Conclusion: ZZD might relieve the hemopoietic inhibition so as to promote the recovery of hemopoietic function through improving the T-lymphocyte subset and reducing the release of hemopoietic negative ragulatory factors such as TNF-α and IL-2 etc.

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