女贞养阴颗粒对美多巴为主抗震颤麻痹增效减毒作用的临床观察

Clinical Observation on the Efficacy Enhancing and Toxicity Attenuating Effect of Nuzhen Yangyin Granule to the Anti-Parkinsonism Therapy Mainly with Medopa

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中文关键词: 女贞养阴颗粒震颤麻痹美多巴增效减毒

英文关键词:Nuzhen Yangyin Granule paralysis agitans Medopa efficacy enhancing and toxic attenuating effect

基金项目:湖南省中医药管理局资助项目(No.20328)

作者	单位
胡学军	湖南省中医药研究院附属医院
杨晓苏	中南大学湘雅医学院
杨旭光	湖南省中医药研究院附属医院
周东阳	湖南省中医药研究院附属医院
谭光波	湖南省中医药研究院附属医院
伍大华	湖南省中医药研究院附属医院
阳立	湖南省中医药研究院附属医院

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中文摘要:

目的:观察并评价女贞养阴颗粒对美多巴、安坦治疗震颤麻痹的增效与减毒作用。方法:采用随机双盲方法,对因服美多巴、安坦疗效衰减或出现明显毒副反应的震颤麻痹患者30例加服中药女贞养阴颗粒治疗,并与对照组(加服安慰剂)30例作对比观察。结果:治疗组和对照组的总有效率分别为86.7％和56.7％,证候总进步率分别为90.0％和56.7％,减毒总有效率分别为90.0％和43.3％,两组比较差异均有显著性(P<0.05或P<0.01);同时表明,女贞养阴颗粒对美多巴、安坦在消化系统、神经精神系统、心血管系统的不良反应有明显治疗作用。结论:初步认为女贞养阴颗粒对美多巴、安坦治疗震颤麻痹有明显的增效减毒作用。

英文摘要:

Objective: To observe and assess the efficacy enhancing and toxicity attenuating effect of Nuzhen Yangyin Granule (NYG) to the anti-parkinsonism (paralysis agitans) therapy with Medopa and Artane. Methods: Adopting the randomized double-blinded method, the effect of adding NYG to 30 patients with Parkinsonism in the treated group, who already received anti-Parkinsonism treatment but showing decreased response to Medopa and Artane and with obvious adverse reaction, was observed and controlled by 30 patients treated by adding placebo. Results: The total effective rate in the treated group and the control group was 86.7 % and 56.7% respectively, the total syndrome improving rate was 90 % and 56. 7 % respectively and the toxicity attenuating rate 90 % and 43.3 % respectively, comparison between the two groups showed significant difference (P<0.05 or P<0.01). NYG also showed markedly effective in reducing the adverse reactions of Medopa and Artane on digestive, neuro-psychiatric and cardiovascular system. Conclusion: NYG has obvious efficacy enhancing and toxicity attenuating effects caused by the anti-Parkinsonism treatment with Medopa and Artane.

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