黄芪注射液对法洛四联症患儿根治术后心功能和血流动力学的影响

作者	单位
李自普	青岛大学医学院附属医院山东266003
曹倩	青岛大学医学院附属医院山东266003
邢泉生	青岛大学医学院附属医院山东266003

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中文摘要:

目的 :观察黄芪注射液对法洛四联症 (tetralogyofFallot,TOF)患儿根治术后心功能和血流动力学的影响。方法 :32例TOF患儿分为常规组 (2 0例 )和黄芪组 (12例 ,黄芪注射液每次 15ml,每 12h 1次 ,连续 7天 ,静脉滴注 ) ;应用超声心动图和肺动脉热稀释导管测定TOF患儿的心功能和血流动力学参数。结果 :给予 15ml黄芪注射液后 1h部分心功能和血流动力学参数明显改善 ,但在 2～ 4h内又恢复到用药前水平。连续 7天给予黄芪注射液可逐渐改善TOF患儿术后的心功能和血流动力学状态 ,且随用药时间的延长而明显。黄芪组患儿脱离呼吸机时间、重症监护室 (ICU )停留时间和正性肌力药物静脉应用时间均较常规组明显短 (P <0 0 1)。结论 :黄芪注射液可明显改善TOF患儿术后的心功能和血流动力学状态 ,缩短患儿术后恢复时间。

英文摘要:

Objective: To evaluate the effect of Milkvetch Injection (MI) on cardiac function and hemodynamics in children with tetralogy of Fallot after radical operation. Methods: Thirty-two children with tetralogy of Fallot were divided into two groups, the 20 patients in the control group treated with conventional treatment and the 12 patients in the treated group treated with 15 ml of MI every 12 hrs for 7 days. The cardiac function and hemodynamic parameters were determined by echocardiography and thermodilution catheter inserted in pulmonary artery. Results: Patients′ cardiac function and hemodynamic parameters were improved significantly 1 hr after administering 15 ml of MI Injection, but restored to the level before medication in 2-4 hrs. Administering MI injection for successive 7 days could gradually improve patients′ cardiac function and hemodynamic parameters after operation, and the improvement became more evident with the prolonging time of medication. The intubation time, intensive care unit duration and the time of intravenously administration of inotropic drugs in the treated group were significantly shorter than those in the control group (P<0.01). Conclusion: MI could significantly improve the hemodynamics and cardiac function, and shorten the recovery time in children with tetralogy of Fallot after radical operation.

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