截哮口服液防治病毒诱发小儿哮喘的临床研究

作者	单位
王孟清	湖南中医学院第一附属医院儿科长沙410007
朱晔	湖南中医学院第一附属医院儿科长沙410007
舒兰	湖南中医学院第一附属医院儿科长沙410007
莫非钧	湖南中医学院第一附属医院儿科长沙410007
欧正武	湖南中医学院第一附属医院儿科长沙410007

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中文摘要:

目的 :观察截哮口服液防治病毒诱发小儿哮喘的疗效及可能的作用机理。方法 :将 16 0例有哮喘史的病毒性上呼吸道感染患儿随机分为两组。治疗组患儿在出现急性上呼吸道感染 (AURTI)症状 2 4h内服用截哮口服液 ,对照组使用病毒唑 10～ 15mg·kg- 1·d- 1,疗程均为 7日 ,并观察患儿临床体征、疗效 ,检测肺功能、免疫球蛋白等的变化。结果 :治疗组总有效率 83 8% ,临床控制率 4 8 8% ,与对照组 (分别为6 2 5 %、2 3 8% )比较 ,差异均有显著性 (P <0 0 1)。截哮口服液对患儿FEV1、PEF有明显改善作用 ,与治疗前比较 ,差异有显著性 (P <0 0 1) ,与对照组比较 ,差异亦有显著性 (P <0 0 5 )。治疗组自身前后对照及与对照组治疗后比较IgE降低 ,差异均有显著性 (P <0 0 1) ,IgA、IgG、IgM变化无统计学意义。结论 :截哮口服液有较好的防治病毒诱发小儿哮喘的效果 ;具有改善患儿肺功能 ,调节免疫的作用。

英文摘要:

Objective: To observe the effect and the possible mechanism of Jiexiao Oral Liquid (JXOL) in preventing and curing virus induced asthma in children. Methods: One hundred and sixty patients of acute upper respiratory tract infection (AURTI) with asthma history were randomly dividedinto 2 groups. JXOL was given to the treated group within 24 hrs after occurrence of AURTI symptoms, and virazole of 10～15 mg·kg -1·d -1 was given to the control group, the therapeutic course for both groups was 7 days. Changes of clinical symptoms, signs, therapeutic effect, pulmonary function and immuno-globulin in patients were observed. Results: The total effective rate of the treated group was 83.8%, the clinical control rate was 48.8%, while those in the control group were 62.5% and 23.8% respectively, showing significant difference between them (P<0.01). JXOL could obviously improve the indexes of forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF), reduce the level of IgE, as compared with those before treatment, the difference was significant (P<0.01 or P<0.05); it also showed significant difference as compared with those in the control group after treatment. The changes of IgA, IgG and IgM after treatment showed insignificant difference. Conclusion: JXOL was effective in preventing and curing virus induced asthma in children, it also shows pulmonary function improving and immune regulating effects.

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