丹芍颗粒对紫癜性肾炎患儿血清超氧化物歧化酶活性和丙二醛含量的影响

Effect of Danshao Granule on Serum Superoxide Dismutase Activity and Malonyldialdehyde Content in Children with Henoch-Schonlein Purpura Nephritis

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DOI：

中文关键词: 紫癜性肾炎超氧化物歧化酶丙二醛丹芍颗粒

英文关键词:Henoch-Schonlein purpura nephritis superoxide dismutase malonyldialdehyde Danshao Granule

基金项目:江苏省科技发展计划项目 (No .BS970 66)

作者	单位
金钟大	南京中医药大学附属第一医院
汪受传	浙江大学医学院附属第一医院肾脏病中心
孙轶秋	浙江大学医学院附属第一医院肾脏病中心
朱萱萱	浙江大学医学院附属第一医院肾脏病中心

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中文摘要:

目的 :探讨丹芍颗粒治疗紫癜性肾炎 (HSPN)的作用机制。方法 :将 6 3例紫癜性肾炎患儿随机分为两组 ,治疗组用丹芍颗粒治疗 ,对照组用雷公藤多甙片加复方丹参片治疗 ,疗程 1个月 ,观察治疗后患儿皮肤紫癜、肉眼血尿、高血压及浮肿消退时间 ,治疗前后 2 4h尿蛋白含量、血清IgA、IgG、IgM含量、血清超氧化物歧化酶 (SOD)和丙二醛 (MDA)含量。结果 :治疗组在治疗患儿皮肤紫癜、肉眼血尿方面效果优于对照组 (P <0 0 5 ) ,治疗后两组患儿 2 4h尿蛋白、血清IgA、SOD、MDA含量均有显著改善 ,与治疗前比较 ,差异均有显著性 (P <0 0 1)。其中 2 4h尿蛋白含量及血清SOD、MDA含量 ,治疗后两组比较 ,差异亦有显著性(P <0 0 5 )。结论 :丹芍颗粒可清除自由基对机体造成的损伤 ,是治疗HSPN的理想药物。

英文摘要:

Objective: To explore the effect and mechanism of Danshao Granule (DSG) in treating Henoch-Schonlein purpura nephritis (HSPN) in children. Methods: The 63 patients with HSPN were randomly divided into two groups. The 32 patients in the treated group were treated with DSG and the 31 patients in the control group were treated with Tripterygium polyglycosides tablet and composite Salviae tablet. The therapeutic course for both groups was one month. The skin purpura, macroscopic hematuria, hypertension and edema subsidence time, 24 hrs urinary protein content, serum levels of immunoglobulins (IgA, IgG, IgM), superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) content were observed before and after treatment. Results: Therapeutic effect in the treated group was better than that in the control group in curing skin purpura and macroscopic hematuria (P<0.05). The 24 hrs urinary protein content and serum levels of IgA, SOD and MDA were improved after treatment in both groups significantly (P<0.01). However, the improvement of 24 hrs urinary protein, serum SOD and MDA in the treated group was more significant than that in the control group respectively (P<0.05). Conclusion: DSG can alleviate the injury of free radicals in organism, so it is an ideal remedy for treatment of HSPN.

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