脑热清口服液结合西药治疗颅脑手术后发热的证-效关系研究

Study on the Syndrome-Effect Relationship of Treatment for Post-Craniotomy Fever Treated by Combination of Naoreqing Oral Liquid and Western Medicine

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中文关键词: 脑热清口服液颅脑手术发热中医证-效关系

英文关键词:Naoreqing oral liquid cranial operation fever TCM Syndrome-effect relationship

基金项目:北京市科委资助课题(No.954024200)

作者	单位
樊永平	首都医科大学附属北京天坛医院
李艳	首都医科大学附属北京天坛医院
胡以明	首都医科大学附属北京天坛医院
张琨	北京医学会
张庆	首都医科大学附属北京中医医院

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中文摘要:

目的观察脑热清口服液(简称脑热清)对颅脑手术后发热的退热疗效及中医证型与疗效关系。方法按天坛医院神经外科3个自然病区随机分为3组,对颅脑手术后患者分别用脑热清(脑热清组,86例)、脑热清结合西药(结合组,276例)和西药(西药组,89例)治疗,比较3组退热幅度和退热疗效,结合组中医证型与退热疗效的关系,并观察各种证型治疗前后主要症状的积分变化。结果脑热清组和结合组退热幅度、退热总有效率均明显优于西药组(P<0.01);结合组中医证型的退热疗效从高到低顺序为湿热内蕴型>内热炽盛型>痰热内阻型,且中医证型的主要症状有显著的改善。结论脑热清结合西药对颅脑手术后发热有确切的退热作用,退热效果与中医证型有关,退热的同时能明显改善其临床主要症状。

英文摘要:

To observe the antifebrile effect of Naoreqing oral liquid (NRQ) in treating post-craniotomic fever, its relationship with the Syndrome type of fever, and the effect of treatment in improving main symptoms. Methods Patients were randomly divided, according to the ward they accommodated, into three groups, the 86 patients in the TCM group treated with NRQ, the 276 in the TCM-WM group with NRQ plus western medicine (WM) and the 89 in the WM group with WM alone. The antifebrile effect of treatment and the degree of body temperature subsidence in groups were compared, relationship between TCM Syndrome type and antifebrile effect was analyzed and the changes of scores of main symptoms before and after treatment were observed. Results The degree of body temperature subsidence and the total antifebrile effective rate in the TCM and the TCM-WM group were similar and better than those in the WM group (P<0.01). In the TCM-WM group, the antifebrile effects in patients with various Syndrome types, in high to low order, were Dampness-Heat type > Inner-Heat type > Phlegm-Heat type, and the treatment showed definite antifebrile effect in improving main symptoms of patients of various types. Conclusion Combination of NRQ and WM has definite antifebrile effect in treating post-craniotomic fever, in a Syndrome-effect dependent manner. At the same time, it also could markedly relieve the various symptoms in patients.

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