中药治疗对反复自然流产患者抗CD抗原封闭效率和血清泌乳素及孕酮的影响

Effect of Chinese Herbal Treatment on the Efficiency of Blocking CD Antigen and on Prolactin and Progesterone in Women with Recurrent Spontaneous Abortion

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中文关键词: 反复自然流产保胎冲剂封闭抗体泌乳素孕酮

英文关键词:recurrent spontaneous abortion Baotai granule blocking antibody prolactin progesterone

基金项目:

作者	单位
张剑峰	复旦大学附属妇产科医院上海200011
归绥琪	复旦大学附属妇产科医院上海200011

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中文摘要:

目的　探讨中药治疗对反复自然流产患者抗CD抗原封闭效率和血清泌乳素 (PRL)、孕酮 (P)的影响。方法　用自制保胎冲剂 (由党参、白术、白芍、黄芩、苏梗、桑寄生、菟丝子等组成 )每日 2次 ,每次 1包(10 g)口服治疗反复自然流产患者 34例 ,观察治疗前后患者血清中封闭抗体对配偶外周血T淋巴细胞CD抗原封闭效率以及血PRL、P的变化。结果　保胎成功 30例 ,占 88 2 % ,治疗后抗CD3、CD4 和CD8的封闭效率均明显高于治疗前。同时外周血PRL、P水平随孕期增加显著升高 ,而保胎失败者无明显变化。结论　中药可能通过调节母胎内分泌和免疫网络的相互应答达到保胎治疗作用。

英文摘要:

Objective To explore the effect of Chinese herbal medicine Baotai Granule （BTG,a self-made preparation） on CD antigen blocking efficiency,prolactin （PRL） and progesterone （P） in patients with recurrent spontaneous abortion （RSA）. Methods Thirty-four women suffered from RSA were treated with BTG,twice every day,1 package （10 g） in each time by orally intake. Changes of the efficiency of serum blocking antibody in them to the CD antigen in their husband’s peripheral T-lymphocytes before and after treatment were observed. And the changes of blood levels of PRL and P were also monitored. Results Fetus had successfully protected in 30 women （88.2%）, in them,the efficiency of blocking to CD₃, CD₄ and CD₈ after treatment were all higher than that before treatment,and levels of PRL and P in peripheral blood increased along with the increase of gestational age,while no obvious change was found in those who failed to complete pregnancy. Conclusion Chinese herbal medicine could protect the fetus by regulating the response between endocrine and immunity network during pregnancy.

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