探讨不孕患者抗精子抗体阳性与一氧化氮水平的关系及中西医结合治疗方法

Exploration on the Relationship between Positive Antisperm Antibody and Nitric Oxide Level of Infertile Patients and on Integrative Chinese and Western Medicine Treatment

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DOI：

中文关键词: 不孕抗精子抗体黄体功能不健一氧化氮

英文关键词:infertility antisperm antibody corpus luteum insufficiency nitric oxide

基金项目:

作者	单位
廖玎玲	江西医学院第二附属医院妇产科南昌330006
余立群	江西医学院第二附属医院妇产科南昌330006
辛华	江西医学院第二附属医院妇产科南昌330006
谭布珍	江西医学院第二附属医院妇产科南昌330006
贺晓菊	江西医学院第二附属医院妇产科南昌330006

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中文摘要:

目的　探讨不孕患者血中抗精子抗体 (AsAb)阳性与一氧化氮 (NO)含量的关系及中西医结合治疗方法。方法　选择 75例AsAb阳性和 6 8例AsAb阴性不孕患者 ,采用中西医结合治疗 ,并随访 5年 ,观察两组足月妊娠率和流产率。治疗前均检测血清NO水平 ,观察其与AsAb阳性的关系。结果　AsAb阳性者血清NO水平显著高于正常育龄妇女 (P <0 0 1) ,AsAb阴性者血清NO水平与正常育龄妇女比较 ,差异无显著性。治疗后 5年足月妊娠分娩差异无显著性 (P >0 0 5 )。结论AsAb阳性和NO水平异常可能互相影响 ,干扰生殖过程。中西医结合治疗能有效调节自身免疫及内分泌功能 ,使AsAb阳性不孕患者获得满意的疗效。

英文摘要:

Objective To study the relationship between the positive antisperm antibody (AsAb) and nitric oxide (NO) content in blood of infertile patients and the therapeutic effect of integrative Chinese and western medicine (ICWM) treatment on the disease. Methods Infertile patients,75 of AsAb positive and 68 of AsAb negative were selected to observe the mature partuient rate and abortion rate. Serum NO level were measured before treatment to observe the relationship between NO and positive AsAb. Patients were treated with ICWM and followed-up for five years. Results Mean value of serum NO in patients with positive AsAb was significantly higher than that in fertile women,and there was no significant difference between patients with negative AsAb and fertile women (P<0.01). In the 5 years after treatment,the mature partuient rate between the two groups showed insignificant difference (P>0.05). Conclusion AsAb positive and NO level abnormal may interfere mutually,to intervent the reproductive process. ICWM therapy could effectively regulate auto-immunity and endocrine function,and make the infertile patients obtain satisfactory efficacy.

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