泰脂安与普伐他汀对老年冠心病患者血管内皮功能影响的比较

作者	单位
戚本玲	华中科技大学同济医学院附属协和医院老年病科
成蓓	华中科技大学同济医学院附属协和医院老年病科
张俏红	广东省梅州市第三人民医院超声检查室

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中文摘要:

目的通过观察泰脂安与普伐他汀对老年冠心病患者血管内皮功能的影响,进一步阐明泰脂安的抗动脉粥样硬化作用,为其应用于冠心病的预防提供理论依据。方法 78例老年冠心病患者,随机分为泰脂安组(39例)及普伐他汀组(39例),运用无创超声检查技术,观察用药前后的颈动脉内-中膜厚度(IMT)及肱动脉内皮依赖性舒张功能(FMD)的变化,同时,检测血清一氧化氮(NO)及血浆内皮素-1(ET-1)的浓度变化。结果治疗后泰脂安组,IMT由(1.21±0.17)mm降至(0.91±0.13)mm,FMD由(5.02±0.58)％上升为(8.97±0.39)％,ET-1由(95.93±19.41)ng/L降至(49.35±53.27)ng/L,NO由(42.56±14.12)μmol/L上升至(69.84±21.96)μmol/L,差异均有显著性(P<0.05,P<0.01);普伐他汀组,IMT由(1.25±0.21)mm降至(0.88±0.32)mm,FMD由(4.90±0.37)％上升为(8.12±0.25)％,ET-1由(89.35±10.02)ng/L降至(47.96±11.05)ng/L,NO由(51.71±9.39)μmol/L上升至(72.93±16.51)μmol/L,差异均有显著性(P<0.05,P<0.01)。结论泰脂安能够明显改善老年冠心病患者血管内皮功能,具有与普伐他汀相似的抗动脉粥样硬化的作用。

英文摘要:

To explore the anti-atherosclerosis effect of Taizhi’an Capsule (TZA) for providing a theoretical base of its application in preventing coronary heart disease (CHD) , by way of observing the effects of TZA and pravastatin (PVT) on vascular endothelial function in senile patients with CHD. Methods seventy-eight Senile patients with CHD were randomly divided into the TZA group and the PVT group, 39 in each group. Changes of carotid arterial intima-media thickness (IMT) and brachial arterial endothelium dependent diastolic function (FMD) before and after treatment were observed by non-invasive ultrasound test technique, and levels of serum nitric oxide (NO) and plasma endothelin-1 (ET-1) were determined as well. Results After TAZ treatment, IMT decreased from 1.21±0.17 mm to 0.91±0.13 mm,FMD increased from 5.02±0.58% to 8.97±0.39% ,ET-1 lowered from 95.93±19.41 ng/L to 49.35±53.27 ng/L,and NO enhanced from 42.56±14.12 μmol/L to 69.84±21.96 μmol/L; after PVT treatment, the corresponding changes were 1.25±0.21 mm to 0.88±0.32 mm,4.90±0.37% to 8.12±0.25% ,89.35±10.02ng/L to 47.96±11.05 ng/L and 51.71±9.39 μmol/L to 72 .93±16.51 μmol/L, all the changes were statistically significant. Conclusion TZA can obviously improve the vascular endothelial function in old patients with CHD, which has the anti-atherosclerosis effect similar to that of PVT.

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