红花注射液对大鼠心脏能荷值及抗凋亡基因bcl-2的影响

作者	单位
张素清	北京中医药大学；中国科学院生物物理研究所
姜良铎	北京中医药大学；中国科学院生物物理研究所

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中文摘要:

目的探讨红花注射液的心脏保护作用及其对心肌组织能荷值、抗细胞凋亡基因bcl-2的影响。方法采用大鼠Langendorff离体心脏灌注模型,在改良的Euro-Collins心脏保存液(mEC液)中添加红花注射液与单纯mEC液作对照,观察其对保存心脏的心功能、能荷值及bcl-2表达的影响。结果与对照组比较红花注射液可改善大鼠心脏的收缩和舒张功能,增加冠脉流量,增强bcl-2的蛋白表达。结论红花注射液具有很好的心脏保护作用。

英文摘要:

To study the effect of safflower injection (SI) in protecting heart, and on energy charge and an-ti-apoptosis gene bcl-2 in cardiac tissue. Methods Rats’ Langendorff isolated heart infused model was used in the experiment to study the effect of SI by measuring the cardiac function, energy charge and bcl-2 expression of the cultured heart in the medified Euro-Collins (mEC) heart preserving liquid with or without addition of SI. Results As compared with the control, SI showed the effects of improving functions of cardiac contraction and dilation, increasing coronary blood flow, and strengthening the bcl-2 protein expression. Conclusion SI has excellent effect in protecting heart.

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