益气养阴活血中药结合西药改善成人缓慢进展型自身免疫性糖尿病胰岛β细胞功能的研究

Study on Improvement of Islet β Cell Function in Patients with Latent Autoimmune Diabetes Mellitus in Adults by Integrative Chinese and Western Medicine

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DOI：

中文关键词: 益气养阴活血中药成人缓慢进展型自身免疫性糖尿病胰岛素胰岛β细胞血糖糖化血红蛋白 C肽

英文关键词:Chinese drugs of benefiting Qi, nourishing Yin, and activating the blood circulation latent autoimmune diabetes mellitus in adults insulin islet β cell blood glucose glycohemoglobin C-peptide

基金项目:

作者	单位
朱立群	广州中医药大学第二附属医院内分泌科
刘英华	广州中医药大学第二附属医院内分泌科
黄曼	天津市和平区中医医院
魏华	广州中医药大学第二附属医院内分泌科
刘振杰	广州中医药大学第二附属医院内分泌科

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全文下载次数: 2001

中文摘要:

目的探讨益气养阴活血中药 (简称中药 )结合西药对成人缓慢进展型自身免疫性糖尿病 (LA DA)患者胰岛 β细胞功能的改善作用。方法将 84例LADA患者随机分为 3组 ,分别用磺脲类降糖药 (A组 2 0例 )、胰岛素 (B组 33例 )及胰岛素加中药 (C组 31例 )联合治疗 ,观察治疗前后血糖、糖化血红蛋白及胰岛β细胞功能的变化。结果A组患者胰岛 β细胞功能的受损没有得到改善 ,C肽分泌峰值仍然较低而且后延 ,而B组和C组患者口服葡萄糖耐量试验后的C肽分泌峰均有提前 ,表明B、C两组患者胰岛β细胞功能均有不同程度改善和恢复 ,但C组患者的效果最好。结论中药具有一定程度的降低血糖和改善糖尿病患者胰岛 β细胞功能的作用 ,与胰岛素联用具有协同和增效作用。对于LADA患者 ,应尽早采用胰岛素或胰岛素与中药联合治疗

英文摘要:

ObjectiveTo study the effect of integrative Chinese and Western medicine (ICWM) on improvement of the islet β cell function in treating patients with latent autoimmune diabetes mellitus in adults (LADA). Methods Eighty-four patients of LADA were randomly divided into 3 groups (20 in A, 33 in B and 31 in C), they were treated respectively with sulfonylurea, insulin and combination of insulin and Chinese medicine. The changes before and after treatment in blood glucose, glycohemoglobin and islet β cell function were observed. Results After treatment, the damaged islet β cell function in Group A was not improved, the secrete peak value of C-peptide was still low and delayed in Group A, but in Group B and C, it shifted earlier, suggesting that a certain degree of improvement and recovery of islet β cell function. The improving effect in Group C was better. ConclusionChinese herbal medicine had effect in lowering blood glucose and improving islet β cell function in patients with diabetes mellitus, and showed a synergistic and enhancing action when combined use with insulin. Early treatment of insulin or combination of insulin and Chinese medicine should be applied to patients with LADA.

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