芪连汤与降糖药联合干预2型糖尿病胰岛素抵抗及对相关炎症细胞因子的影响

Preliminary Exploration on Effect of Qilian Decoction in Intervention Treatment of Diabetes Mellitus Type 2 with Insulin Resistance and Its Influence on Related Inflammatory Cytokines

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中文关键词: 芪连汤 2型糖尿病胰岛素抵抗炎症细胞因子胰岛素敏感指数

英文关键词:Qilian decoction diabetes mellitus type 2 insulin resistance inflammatory cytokine insulin senitive index

基金项目:

作者	单位
高书荣	上海市普陀区人民医院中医科
卜建宏	上海市普陀区人民医院中医科
朱良争	上海龙华医院

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中文摘要:

目的观察芪连汤与相应降糖药协同对 2型糖尿病患者胰岛素敏感性的作用及相关炎症细胞因子的影响。方法选择 2型糖尿病患者 6 2例 ,随机分为两组 ,两组均常规应用西药降糖药 ,治疗组同时加用芪连汤口服 ,每日 1剂 ,分 2次服 ,疗程 4周。并测定两组治疗前后空腹血糖、胰岛素、C肽、肿瘤坏死因子α(TNFα)、C反应蛋白 (CRP)、白细胞介素 6 (IL 6 )含量 ,计算胰岛素敏感指数 (ISI)。结果两组空腹血糖治疗后均比治疗前显著下降 (P <0 0 1) ;治疗组胰岛素、C肽、ISI、TNFα、IL 6和CRP含量治疗后比治疗前明显下降 (P <0 0 5或P <0 0 1) ,且治疗组优于对照组 (P <0 0 5或P <0 0 1)。结论芪连汤对改善胰岛素抵抗及降低相关炎症细胞因子水平有一定作用

英文摘要:

ObjectiveTo observe the synergistic effect of Qilian decoction (QLD) with corresponding hypoglycemic agents on insulin sensitivity in patients with diabetes mellitus type 2 and its influence on related inflammatory cytokines. MethodsSixty-two patients with diabetes mellitus type 2 were selected and randomly divided into two groups, they were treated with hypoglycemic agent in routine, and QLD was given orally, one dose taken in twice a day. Parameters as fasting blood glucose, insulin, peptide C, tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin 6 (IL-6) were measured before and after treatment, and insulin sensitive index (ISI) was also calculated. ResultsThe level of fasting blood glucose lowered after treatment in both groups (P<0 01); levels of fasting insulin, peptide C, ISI, TNF-α, IL-6 and CRP significantly lowered after treatment (P<0 05 or P<0 01), and the effect was better than that in the control group (P<0 05 or P<0 01). ConclusionQLD could improve the insulin resistance and lower the levels of related inflammatory cytokines.

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